Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for ZNF426. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF426 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF426, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:9,309,252–9,310,462 | 228.7 kb | Distal (>10kb) Multiome | 627 | |
| chr19:9,323,540–9,324,623 | 214.4 kb | Distal (>10kb) Multiome | 577 | |
| chr19:9,435,095–9,435,909 | 103.0 kb | Distal (>10kb) Multiome | 701 | |
| chr19:9,538,339–9,539,009 | 120 bp | At TSS Multiome | 759 | |
| chr19:9,582,064–9,582,785 | 43.9 kb | Distal (>10kb) Multiome | 99 | |
| chr19:9,584,055–9,584,863 | 46.0 kb | Distal (>10kb) Multiome | 801 | |
| chr19:9,620,792–9,622,027 | 82.7 kb | Distal (>10kb) Multiome | 856 | |
| chr19:9,674,791–9,675,456 | 136.5 kb | Distal (>10kb) Multiome | 793 | |
| chr19:9,768,230–9,769,267 | 230.1 kb | Distal (>10kb) Multiome | 893 | |
| chr19:9,784,209–9,786,632 | 247.2 kb | Distal (>10kb) Multiome | 727 | |
| chr19:9,791,515–9,793,483 | 254.2 kb | Distal (>10kb) Multiome | 507 | |
| chr19:9,818,302–9,820,113 | 280.8 kb | Distal (>10kb) Multiome | 870 | |
| chr19:9,827,304–9,828,194 | 289.2 kb | Distal (>10kb) Multiome | 742 | |
| chr19:9,834,598–9,835,806 | 296.5 kb | Distal (>10kb) Multiome | 681 |
Genomic view of the ZNF426 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.