Enables heme binding activity. Involved in adipose tissue development. Located in endoplasmic reticulum and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PGRMC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PGRMC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PGRMC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:128,054,858–128,056,003 | 232.2 kb | Distal (>10kb) Multiome | 126 | |
| chr4:128,060,601–128,062,576 | 226.7 kb | Distal (>10kb) Multiome | 1009 | |
| chr4:128,286,527–128,289,249 | 210 bp | At TSS Multiome | 1136 | |
| chr4:128,295,233–128,295,606 | 7.4 kb | Proximal (<10kb) | 8 | |
| chr4:128,560,580–128,561,830 | 273.5 kb | Distal (>10kb) Multiome | 273 | |
| chr4:128,866,342–128,867,421 | 579.1 kb | Distal (>10kb) Multiome HiCAR | 129 |
Genomic view of the PGRMC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.