This gene encodes a protein containing domains found in the La related protein of Drosophila melanogaster. La motif-containing proteins are thought to be RNA-binding proteins, where the La motif and adjacent amino acids fold into an RNA recognition motif. The La motif is also found in proteins unrelated to the La protein. Alternative splicing has been observed at this locus and multiple variants, encoding distinct isoforms, are described. Additional splice variation has been identified but the full-length nature of these transcripts has not been determined. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for LARP1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LARP1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LARP1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:127,772,776–127,773,663 | 288.0 kb | Distal (>10kb) Multiome | 169 | |
| chr4:127,781,184–127,783,476 | 279.1 kb | Distal (>10kb) Multiome | 938 | |
| chr4:127,845,791–127,846,800 | 215.0 kb | Distal (>10kb) Multiome | 146 | |
| chr4:127,880,303–127,882,032 | 180.1 kb | Distal (>10kb) Multiome | 933 | |
| chr4:127,963,708–127,966,116 | 96.0 kb | Distal (>10kb) Multiome | 986 | |
| chr4:128,054,858–128,056,003 | 5.7 kb | Proximal (<10kb) Multiome | 126 | |
| chr4:128,060,601–128,062,576 | 133 bp | At TSS Multiome | 1009 | |
| chr4:128,069,004–128,069,204 | 7.7 kb | Proximal (<10kb) | 33 | |
| chr4:128,286,527–128,289,249 | 226.7 kb | Distal (>10kb) Multiome | 1136 |
Genomic view of the LARP1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.