ZBTB8A

zinc finger and BTB domain containing 8A | BOZF1, FLJ90065, ZNF916A, ZBTB8

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC6

Biological processes 11 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)transcription cis-regulatory region binding (GO:0000976)transcription coactivator binding (GO:0001223)

Expression (TPM)

TFs regulating ZBTB8A 0 TFs

Transcription factors with Perturb-seq knockdown data for ZBTB8A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB8A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZBTB8A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB8A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:32,239,728–32,240,979	299.0 kb	Distal (>10kb) Multiome	456
chr1:32,248,081–32,248,895	291.0 kb	Distal (>10kb) Multiome	622
chr1:32,291,710–32,292,726	247.4 kb	Distal (>10kb) Multiome	900
chr1:32,334,713–32,336,836	203.2 kb	Distal (>10kb) Multiome	804
chr1:32,351,055–32,352,355	187.9 kb	Distal (>10kb) Multiome	944
chr1:32,361,365–32,362,459	177.3 kb	Distal (>10kb) Multiome	305
chr1:32,393,928–32,395,356	144.8 kb	Distal (>10kb) Multiome	930
chr1:32,437,702–32,438,502	101.2 kb	Distal (>10kb) Multiome	85
chr1:32,439,697–32,440,223	99.5 kb	Distal (>10kb) Multiome	40
chr1:32,464,697–32,465,552	74.4 kb	Distal (>10kb) Multiome	408
chr1:32,500,363–32,501,049	38.7 kb	Distal (>10kb) Multiome	540
chr1:32,520,498–32,520,989	18.7 kb	Distal (>10kb) Multiome	384
chr1:32,539,285–32,540,081	316 bp	At TSS Multiome	434
chr1:32,540,505–32,541,033	1.4 kb	Proximal (<10kb) Multiome	172
chr1:32,611,983–32,612,668	72.9 kb	Distal (>10kb) Multiome	560
chr1:32,643,807–32,644,727	104.8 kb	Distal (>10kb) Multiome	70
chr1:32,650,248–32,651,874	111.6 kb	Distal (>10kb) Multiome	1164
chr1:32,712,054–32,712,688	173.0 kb	Distal (>10kb) Multiome	645
chr1:32,715,926–32,717,303	177.4 kb	Distal (>10kb) Multiome	551
chr1:32,736,558–32,737,765	197.6 kb	Distal (>10kb) Multiome	507
chr1:32,753,606–32,755,507	214.5 kb	Distal (>10kb) Multiome	565
chr1:32,758,502–32,759,280	219.4 kb	Distal (>10kb) Multiome	144
chr1:32,765,137–32,765,925	226.3 kb	Distal (>10kb) Multiome	122
chr1:32,772,938–32,773,451	233.7 kb	Distal (>10kb) Multiome	441
chr1:32,816,876–32,818,654	278.1 kb	Distal (>10kb) Multiome	1138

Genome Browser

Genomic view of the ZBTB8A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.