This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]
Transcription factors with Perturb-seq knockdown data for ZNF266. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF266 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF266, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:9,140,232–9,140,885 | 295.1 kb | Distal (>10kb) Multiome | 722 | |
| chr19:9,309,252–9,310,462 | 125.6 kb | Distal (>10kb) Multiome | 627 | |
| chr19:9,323,540–9,324,623 | 111.4 kb | Distal (>10kb) Multiome | 577 | |
| chr19:9,431,565–9,431,825 | 3.7 kb | Proximal (<10kb) | 51 | |
| chr19:9,435,095–9,435,909 | 42 bp | At TSS Multiome | 701 | |
| chr19:9,538,339–9,539,009 | 103.2 kb | Distal (>10kb) Multiome | 759 | |
| chr19:9,582,064–9,582,785 | 146.9 kb | Distal (>10kb) Multiome | 99 | |
| chr19:9,584,055–9,584,863 | 149.1 kb | Distal (>10kb) Multiome | 801 | |
| chr19:9,620,792–9,622,027 | 185.8 kb | Distal (>10kb) Multiome | 856 | |
| chr19:9,674,791–9,675,456 | 239.6 kb | Distal (>10kb) Multiome | 793 |
Genomic view of the ZNF266 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.