Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZFP14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFP14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFP14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:36,113,981–36,116,196 | 263.9 kb | Distal (>10kb) Multiome | 1052 | |
| chr19:36,127,575–36,128,707 | 251.2 kb | Distal (>10kb) Multiome | 942 | |
| chr19:36,139,425–36,141,811 | 237.9 kb | Distal (>10kb) Multiome | 1037 | |
| chr19:36,160,493–36,161,405 | 218.3 kb | Distal (>10kb) Multiome | 94 | |
| chr19:36,214,162–36,215,543 | 164.4 kb | Distal (>10kb) Multiome | 1008 | |
| chr19:36,245,106–36,245,849 | 133.8 kb | Distal (>10kb) Multiome | 153 | |
| chr19:36,331,415–36,332,377 | 47.4 kb | Distal (>10kb) Multiome | 372 | |
| chr19:36,378,606–36,379,573 | 55 bp | At TSS Multiome | 839 | |
| chr19:36,418,146–36,419,031 | 39.5 kb | Distal (>10kb) Multiome | 638 | |
| chr19:36,488,856–36,490,274 | 110.4 kb | Distal (>10kb) Multiome | 991 | |
| chr19:36,527,962–36,529,500 | 149.3 kb | Distal (>10kb) Multiome | 937 | |
| chr19:36,572,622–36,573,936 | 194.1 kb | Distal (>10kb) Multiome | 1017 | |
| chr19:36,604,710–36,605,744 | 226.1 kb | Distal (>10kb) Multiome | 657 | |
| chr19:36,666,500–36,667,489 | 287.7 kb | Distal (>10kb) Multiome | 842 |
Genomic view of the ZFP14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.