This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for PLK4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLK4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLK4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:127,604,816–127,605,606 | 275.8 kb | Distal (>10kb) Multiome | 211 | |
| chr4:127,622,432–127,623,976 | 257.8 kb | Distal (>10kb) Multiome | 465 | |
| chr4:127,632,393–127,633,532 | 248.0 kb | Distal (>10kb) Multiome | 537 | |
| chr4:127,772,776–127,773,663 | 107.7 kb | Distal (>10kb) Multiome | 169 | |
| chr4:127,781,184–127,783,476 | 98.7 kb | Distal (>10kb) Multiome | 938 | |
| chr4:127,845,791–127,846,800 | 34.6 kb | Distal (>10kb) Multiome | 146 | |
| chr4:127,880,303–127,882,032 | 243 bp | At TSS Multiome | 933 | |
| chr4:127,963,708–127,966,116 | 84.4 kb | Distal (>10kb) Multiome | 986 | |
| chr4:128,054,858–128,056,003 | 174.7 kb | Distal (>10kb) Multiome | 126 | |
| chr4:128,060,601–128,062,576 | 180.2 kb | Distal (>10kb) Multiome | 1009 |
Genomic view of the PLK4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.