This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]
Transcription factors with Perturb-seq knockdown data for ZNF384. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF384 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF384, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:6,451,305–6,451,838 | 238.0 kb | Distal (>10kb) Multiome | 535 | |
| chr12:6,469,922–6,471,399 | 218.6 kb | Distal (>10kb) Multiome | 930 | |
| chr12:6,492,998–6,494,331 | 196.1 kb | Distal (>10kb) Multiome | 936 | |
| chr12:6,533,253–6,535,726 | 155.1 kb | Distal (>10kb) Multiome | 1131 | |
| chr12:6,539,914–6,540,883 | 148.8 kb | Distal (>10kb) Multiome | 427 | |
| chr12:6,554,111–6,554,621 | 135.2 kb | Distal (>10kb) Multiome | 407 | |
| chr12:6,555,532–6,556,318 | 133.4 kb | Distal (>10kb) Multiome | 551 | |
| chr12:6,567,822–6,568,719 | 121.1 kb | Distal (>10kb) Multiome | 837 | |
| chr12:6,605,947–6,607,790 | 82.0 kb | Distal (>10kb) Multiome HiCAR | 774 | |
| chr12:6,613,155–6,614,551 | 75.4 kb | Distal (>10kb) Multiome | 810 | |
| chr12:6,620,128–6,620,868 | 68.9 kb | Distal (>10kb) Multiome | 239 | |
| chr12:6,662,802–6,663,663 | 26.2 kb | Distal (>10kb) Multiome HiCAR | 868 | |
| chr12:6,688,517–6,690,027 | 2 bp | At TSS Multiome | 943 | |
| chr12:6,697,929–6,698,125 | 9.0 kb | Proximal (<10kb) | 153 | |
| chr12:6,699,959–6,700,887 | 11.0 kb | Distal (>10kb) Multiome | 263 | |
| chr12:6,723,658–6,724,773 | 34.6 kb | Distal (>10kb) Multiome | 1065 | |
| chr12:6,752,554–6,754,332 | 64.0 kb | Distal (>10kb) Multiome | 975 | |
| chr12:6,763,677–6,764,983 | 74.9 kb | Distal (>10kb) Multiome | 570 | |
| chr12:6,765,172–6,767,791 | 76.9 kb | Distal (>10kb) Multiome | 824 | |
| chr12:6,768,329–6,769,331 | 79.6 kb | Distal (>10kb) Multiome | 249 | |
| chr12:6,778,736–6,779,459 | 89.6 kb | Distal (>10kb) Multiome | 777 | |
| chr12:6,821,268–6,822,155 | 132.3 kb | Distal (>10kb) Multiome | 299 | |
| chr12:6,825,458–6,825,915 | 136.2 kb | Distal (>10kb) Multiome | 404 | |
| chr12:6,828,101–6,829,966 | 140.1 kb | Distal (>10kb) Multiome | 689 | |
| chr12:6,851,017–6,853,279 | 162.9 kb | Distal (>10kb) Multiome | 966 | |
| chr12:6,866,801–6,870,175 | 178.0 kb | Distal (>10kb) Multiome | 887 | |
| chr12:6,871,062–6,874,199 | 182.9 kb | Distal (>10kb) Multiome | 947 | |
| chr12:6,890,735–6,891,820 | 201.8 kb | Distal (>10kb) Multiome | 908 | |
| chr12:6,904,217–6,905,282 | 215.4 kb | Distal (>10kb) Multiome | 566 | |
| chr12:6,914,274–6,914,898 | 225.0 kb | Distal (>10kb) Multiome | 536 | |
| chr12:6,924,156–6,924,592 | 235.0 kb | Distal (>10kb) Multiome | 458 | |
| chr12:6,925,828–6,926,431 | 236.5 kb | Distal (>10kb) Multiome | 407 | |
| chr12:6,927,411–6,928,051 | 238.4 kb | Distal (>10kb) Multiome | 493 | |
| chr12:6,936,709–6,938,342 | 248.6 kb | Distal (>10kb) Multiome | 1008 | |
| chr12:6,942,356–6,945,492 | 254.7 kb | Distal (>10kb) Multiome | 1205 | |
| chr12:6,945,587–6,947,099 | 257.0 kb | Distal (>10kb) Multiome | 618 | |
| chr12:6,961,769–6,963,542 | 273.7 kb | Distal (>10kb) Multiome | 682 | |
| chr12:6,964,932–6,965,569 | 275.8 kb | Distal (>10kb) Multiome | 549 | |
| chr12:6,970,111–6,971,189 | 281.3 kb | Distal (>10kb) Multiome | 899 |
Genomic view of the ZNF384 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.