Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol; nucleolus; and nucleoplasm. Biomarker of in situ carcinoma and seminoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF354A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF354A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF354A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:178,470,038–178,470,701 | 260.1 kb | Distal (>10kb) Multiome | 49 | |
| chr5:178,563,529–178,564,357 | 166.6 kb | Distal (>10kb) Multiome | 28 | |
| chr5:178,565,213–178,565,920 | 165.1 kb | Distal (>10kb) Multiome | 25 | |
| chr5:178,589,202–178,590,958 | 140.1 kb | Distal (>10kb) Multiome | 378 | |
| chr5:178,626,153–178,627,627 | 103.6 kb | Distal (>10kb) Multiome | 927 | |
| chr5:178,730,157–178,730,973 | 68 bp | At TSS Multiome | 717 | |
| chr5:178,778,843–178,779,399 | 48.4 kb | Distal (>10kb) Multiome | 165 | |
| chr5:178,859,723–178,860,476 | 129.3 kb | Distal (>10kb) Multiome | 813 | |
| chr5:178,895,613–178,896,587 | 165.4 kb | Distal (>10kb) Multiome | 509 | |
| chr5:178,994,469–178,995,315 | 264.2 kb | Distal (>10kb) Multiome | 118 | |
| chr5:179,023,550–179,024,208 | 293.2 kb | Distal (>10kb) Multiome | 632 |
Genomic view of the ZNF354A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.