ZNF580

zinc finger protein 580

Enables sequence-specific double-stranded DNA binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of cell migration; and positive regulation of interleukin-8 production. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1 DE-1.9

Biological processes 17 terms

DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)cellular response to hydrogen peroxide (GO:0070301)chromatin (GO:0000785)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of endothelial cell migration (GO:0010595)positive regulation of endothelial cell proliferation (GO:0001938)positive regulation of gene expression (GO:0010628)positive regulation of interleukin-8 production (GO:0032757)positive regulation of leukocyte chemotaxis (GO:0002690)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific double-stranded DNA binding (GO:1990837)

Expression (TPM)

TFs regulating ZNF580 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF580. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF580 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF580

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF580, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:54,430,381–54,431,285	1211.1 kb	Distal (>10kb) Multiome HiCAR	240
chr19:55,353,720–55,354,487	288.0 kb	Distal (>10kb) Multiome	297
chr19:55,369,099–55,370,447	272.1 kb	Distal (>10kb) Multiome	383
chr19:55,383,539–55,384,553	258.2 kb	Distal (>10kb) Multiome	374
chr19:55,384,697–55,386,560	256.4 kb	Distal (>10kb) Multiome	903
chr19:55,406,950–55,408,675	234.0 kb	Distal (>10kb) Multiome	965
chr19:55,452,738–55,453,308	189.0 kb	Distal (>10kb) Multiome	339
chr19:55,460,784–55,462,230	180.3 kb	Distal (>10kb) Multiome	947
chr19:55,476,048–55,477,307	165.4 kb	Distal (>10kb) Multiome	1007
chr19:55,484,846–55,485,682	156.9 kb	Distal (>10kb) Multiome	594
chr19:55,503,638–55,504,310	138.1 kb	Distal (>10kb) Multiome	710
chr19:55,516,768–55,517,459	125.0 kb	Distal (>10kb) Multiome	583
chr19:55,536,923–55,537,366	104.9 kb	Distal (>10kb) Multiome	180
chr19:55,549,822–55,550,343	92.0 kb	Distal (>10kb) Multiome	396
chr19:55,580,080–55,581,090	61.3 kb	Distal (>10kb) Multiome	718
chr19:55,585,644–55,586,314	56.2 kb	Distal (>10kb) Multiome	370
chr19:55,586,698–55,587,594	54.8 kb	Distal (>10kb) Multiome	463
chr19:55,598,551–55,600,991	41.7 kb	Distal (>10kb) Multiome	1018
chr19:55,604,520–55,606,690	36.8 kb	Distal (>10kb) Multiome	820
chr19:55,623,637–55,625,055	17.6 kb	Distal (>10kb) Multiome	650
chr19:55,632,461–55,632,653	9.4 kb	Proximal (<10kb)	211
chr19:55,634,853–55,635,260	6.8 kb	Proximal (<10kb)	814
chr19:55,640,091–55,641,769	1.1 kb	Proximal (<10kb) Multiome	821
chr19:55,642,197–55,644,356	1.4 kb	Proximal (<10kb) Multiome	884
chr19:55,647,711–55,648,342	6.0 kb	Proximal (<10kb) Multiome	671
chr19:55,652,138–55,653,078	10.3 kb	Distal (>10kb) Multiome	105
chr19:55,653,199–55,656,056	12.6 kb	Distal (>10kb) Multiome	1123
chr19:55,674,767–55,675,613	33.1 kb	Distal (>10kb) Multiome	765

Genome Browser

Genomic view of the ZNF580 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.