Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including mammary gland development; nervous system development; and visual learning. Predicted to be located in chromatin and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FOXB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:59,993,929–59,994,433 | 9.9 kb | Proximal (<10kb) | 119 | |
| chr15:59,994,896–59,995,596 | 8.9 kb | Proximal (<10kb) Multiome | 105 | |
| chr15:59,996,571–59,997,720 | 7.0 kb | Proximal (<10kb) Multiome | 368 | |
| chr15:60,003,712–60,005,614 | 6 bp | At TSS Multiome | 384 | |
| chr15:60,005,938–60,006,820 | 2.3 kb | Proximal (<10kb) Multiome | 389 |
Genomic view of the FOXB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.