The protein encoded by this gene is a member of the krueppel C2H2-type zinc finger protein family. The encoded protein contains five zinc fingers and is likely a nuclear transcriptional regulator. Numerous transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2016]
Transcription factors with Perturb-seq knockdown data for ZNF518A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF518A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF518A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:95,840,547–95,841,469 | 288.8 kb | Distal (>10kb) Multiome | 21 | |
| chr10:95,907,059–95,908,292 | 221.8 kb | Distal (>10kb) Multiome | 823 | |
| chr10:95,920,289–95,921,295 | 209.1 kb | Distal (>10kb) Multiome | 99 | |
| chr10:96,043,065–96,044,649 | 86.2 kb | Distal (>10kb) Multiome | 891 | |
| chr10:96,124,583–96,124,967 | 4.8 kb | Proximal (<10kb) | 556 | |
| chr10:96,129,440–96,130,826 | 400 bp | At TSS Multiome | 1039 | |
| chr10:96,309,703–96,310,258 | 180.3 kb | Distal (>10kb) Multiome | 187 | |
| chr10:96,324,253–96,324,992 | 194.9 kb | Distal (>10kb) Multiome | 66 | |
| chr10:96,375,112–96,375,818 | 245.7 kb | Distal (>10kb) Multiome | 477 |
Genomic view of the ZNF518A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.