SOX15
SRY-box transcription factor 15 | SOX26, SOX27, SOX20

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]

Biological processes 37 terms
DNA binding (GO:0003677)DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)brain development (GO:0007420)cell differentiation (GO:0030154)chromatin (GO:0000785)chromatin binding (GO:0003682)chromatin organization (GO:0006325)cytoplasm (GO:0005737)male gonad development (GO:0008584)myoblast development (GO:0048627)negative regulation of striated muscle tissue development (GO:0045843)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)neuron differentiation (GO:0030182)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of G0 to G1 transition (GO:0070318)positive regulation of G0 to G1 transition (GO:0070318)positive regulation of myoblast proliferation (GO:2000288)positive regulation of myoblast proliferation (GO:2000288)positive regulation of satellite cell activation involved in skeletal muscle regeneration (GO:0014718)positive regulation of satellite cell activation involved in skeletal muscle regeneration (GO:0014718)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)transcription regulator complex (GO:0005667)trophoblast giant cell differentiation (GO:0060707)trophoblast giant cell differentiation (GO:0060707)
Expression (TPM)
SOX15 — as a Regulated Gene

TFs regulating SOX15 0 TFs

Transcription factors with Perturb-seq knockdown data for SOX15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SOX15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SOX15

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SOX15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:7,293,901–7,295,189 295.3 kb Distal (>10kb) Multiome 443
chr17:7,296,224–7,296,683 293.5 kb Distal (>10kb) Multiome 688
chr17:7,306,788–7,309,027 282.7 kb Distal (>10kb) Multiome 896
chr17:7,314,722–7,315,725 274.8 kb Distal (>10kb) Multiome 843
chr17:7,328,881–7,330,972 260.6 kb Distal (>10kb) Multiome 809
chr17:7,349,378–7,350,590 239.8 kb Distal (>10kb) Multiome 414
chr17:7,351,208–7,352,575 238.0 kb Distal (>10kb) Multiome 857
chr17:7,356,082–7,356,523 233.8 kb Distal (>10kb) Multiome 485
chr17:7,383,791–7,384,537 205.9 kb Distal (>10kb) Multiome 218
chr17:7,393,924–7,395,223 195.4 kb Distal (>10kb) Multiome 744
chr17:7,403,290–7,405,695 185.7 kb Distal (>10kb) Multiome 838
chr17:7,435,167–7,437,681 153.0 kb Distal (>10kb) Multiome 828
chr17:7,437,892–7,438,555 151.8 kb Distal (>10kb) Multiome 224
chr17:7,440,048–7,441,211 149.4 kb Distal (>10kb) Multiome 487
chr17:7,444,968–7,446,142 144.5 kb Distal (>10kb) Multiome 632
chr17:7,455,450–7,456,019 134.4 kb Distal (>10kb) Multiome 414
chr17:7,478,839–7,480,126 110.6 kb Distal (>10kb) Multiome 574
chr17:7,483,139–7,485,576 105.6 kb Distal (>10kb) Multiome 1156
chr17:7,548,693–7,549,285 41.1 kb Distal (>10kb) Multiome 387
chr17:7,560,249–7,562,536 28.2 kb Distal (>10kb) Multiome 759
chr17:7,572,039–7,574,418 16.2 kb Distal (>10kb) Multiome 1071
chr17:7,579,018–7,579,876 10.6 kb Distal (>10kb) Multiome 844
chr17:7,583,063–7,584,547 6.3 kb Proximal (<10kb) Multiome 921
chr17:7,588,871–7,590,534 61 bp At TSS Multiome 319
chr17:7,590,769–7,591,007 675 bp At TSS 125
chr17:7,614,065–7,615,780 25.0 kb Distal (>10kb) Multiome 708
chr17:7,627,090–7,628,247 37.7 kb Distal (>10kb) Multiome 712
chr17:7,650,010–7,652,127 60.7 kb Distal (>10kb) Multiome 467
chr17:7,685,876–7,686,907 96.2 kb Distal (>10kb) Multiome 765
chr17:7,687,214–7,687,777 97.4 kb Distal (>10kb) Multiome 710
chr17:7,687,867–7,688,863 98.2 kb Distal (>10kb) Multiome 700
chr17:7,703,383–7,703,975 113.6 kb Distal (>10kb) Multiome 141
chr17:7,704,799–7,705,590 115.0 kb Distal (>10kb) Multiome 325
chr17:7,716,832–7,717,983 127.3 kb Distal (>10kb) Multiome 759
chr17:7,833,417–7,837,960 245.5 kb Distal (>10kb) Multiome 1160
chr17:7,841,438–7,843,228 252.1 kb Distal (>10kb) Multiome 861
chr17:7,843,355–7,844,130 253.5 kb Distal (>10kb) Multiome 614
chr17:7,844,349–7,845,186 254.8 kb Distal (>10kb) Multiome 617
chr17:7,851,538–7,852,239 261.8 kb Distal (>10kb) Multiome 531
chr17:7,856,600–7,858,747 267.4 kb Distal (>10kb) Multiome 942
chr17:7,885,205–7,885,734 295.2 kb Distal (>10kb) Multiome 371
chr17:7,887,616–7,888,198 297.8 kb Distal (>10kb) Multiome 581

Genome Browser

Genomic view of the SOX15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:7,283,901 – 7,898,198
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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