Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF34. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF34 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF34, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:144,495,748–144,496,431 | 291.2 kb | Distal (>10kb) Multiome | 131 | |
| chr8:144,500,182–144,501,505 | 286.3 kb | Distal (>10kb) Multiome | 484 | |
| chr8:144,507,995–144,510,268 | 278.4 kb | Distal (>10kb) Multiome | 1067 | |
| chr8:144,517,168–144,518,442 | 269.4 kb | Distal (>10kb) Multiome | 637 | |
| chr8:144,521,935–144,523,450 | 264.8 kb | Distal (>10kb) Multiome | 663 | |
| chr8:144,524,105–144,525,099 | 262.6 kb | Distal (>10kb) Multiome | 264 | |
| chr8:144,526,399–144,529,305 | 258.5 kb | Distal (>10kb) Multiome | 934 | |
| chr8:144,529,455–144,530,630 | 257.2 kb | Distal (>10kb) Multiome | 284 | |
| chr8:144,580,290–144,581,657 | 206.5 kb | Distal (>10kb) Multiome | 271 | |
| chr8:144,684,108–144,686,340 | 101.4 kb | Distal (>10kb) Multiome | 862 | |
| chr8:144,755,078–144,755,956 | 31.7 kb | Distal (>10kb) Multiome | 769 | |
| chr8:144,785,987–144,788,592 | 120 bp | At TSS Multiome | 997 | |
| chr8:144,791,751–144,793,221 | 5.1 kb | Proximal (<10kb) Multiome | 899 | |
| chr8:144,793,452–144,794,040 | 6.1 kb | Proximal (<10kb) | 126 | |
| chr8:144,798,389–144,799,501 | 11.6 kb | Distal (>10kb) Multiome | 832 | |
| chr8:144,826,059–144,827,981 | 40.0 kb | Distal (>10kb) Multiome | 905 | |
| chr8:144,852,614–144,853,614 | 65.8 kb | Distal (>10kb) Multiome | 850 | |
| chr8:144,900,754–144,902,675 | 114.3 kb | Distal (>10kb) Multiome | 1021 | |
| chr8:144,950,374–144,951,024 | 163.5 kb | Distal (>10kb) Multiome | 695 | |
| chr8:145,002,551–145,003,548 | 215.7 kb | Distal (>10kb) Multiome | 872 | |
| chr8:145,051,576–145,052,751 | 265.0 kb | Distal (>10kb) Multiome | 797 |
Genomic view of the ZNF34 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.