Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in axon development; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II; spinal cord motor neuron cell fate specification; and spinal cord motor neuron migration. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for OLIG3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OLIG3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OLIG3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:137,218,440–137,220,020 | 275.0 kb | Distal (>10kb) Multiome | 954 | |
| chr6:137,297,871–137,298,382 | 196.4 kb | Distal (>10kb) Multiome | 155 | |
| chr6:137,415,163–137,415,926 | 78.7 kb | Distal (>10kb) Multiome | 257 | |
| chr6:137,423,433–137,424,076 | 70.7 kb | Distal (>10kb) Multiome | 183 | |
| chr6:137,487,921–137,490,027 | 5.2 kb | Proximal (<10kb) Multiome | 225 | |
| chr6:137,493,147–137,494,925 | 104 bp | At TSS Multiome | 272 | |
| chr6:137,495,231–137,496,293 | 1.4 kb | Proximal (<10kb) Multiome | 173 | |
| chr6:137,496,396–137,496,721 | 2.0 kb | Proximal (<10kb) | 45 | |
| chr6:137,496,911–137,498,461 | 3.5 kb | Proximal (<10kb) Multiome | 294 | |
| chr6:137,589,211–137,589,906 | 95.2 kb | Distal (>10kb) Multiome HiCAR | 441 |
Genomic view of the OLIG3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.