Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; POZ domain binding activity; and methyl-CpG binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZBTB21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:41,766,154–41,767,269 | 243.3 kb | Distal (>10kb) Multiome | 579 | |
| chr21:41,778,087–41,778,564 | 232.0 kb | Distal (>10kb) Multiome | 367 | |
| chr21:41,878,502–41,879,847 | 131.2 kb | Distal (>10kb) Multiome | 630 | |
| chr21:41,953,094–41,954,549 | 56.3 kb | Distal (>10kb) Multiome | 667 | |
| chr21:42,009,116–42,011,396 | 109 bp | At TSS Multiome | 954 | |
| chr21:42,107,454–42,108,282 | 97.6 kb | Distal (>10kb) Multiome HiCAR | 336 | |
| chr21:42,218,772–42,219,352 | 208.7 kb | Distal (>10kb) Multiome | 258 | |
| chr21:42,234,400–42,235,305 | 224.5 kb | Distal (>10kb) Multiome | 427 |
Genomic view of the ZBTB21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.