chr18:57,430,302–57,431,333

chr18 : 57,430,302 – 57,431,333

1,031 bp 103 TFs 7 linked genes

This 1.0 kb open chromatin element is linked to 7 target genes and is bound by 103 transcription factors.

Linked Genes

7 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ONECUT2		4.0 kb	Proximal	Proximity
ST8SIA3		78.0 kb	Distal	Multiome
FECH		156.0 kb	Distal	Multiome
NARS1		191.1 kb	Distal	Multiome
ATP8B1-AS1		199.6 kb	Distal	Multiome
ENSG00000267787		265.2 kb	Distal	Multiome
WDR7		779.4 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

103 transcription factors

ChIP MCF-7 GSE144036.AFF4.MCF-7 290 bp overlap

ASH2L 1 dataset

ChIP WA01 ENCSR850KIP.ASH2L.WA01 790 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 151 bp overlap

BCOR 3 datasets

ChIP WA01 GSE104690.BCOR.WA01 1031 bp overlap

ChIP WA01_KDM2B_KO GSE104690.BCOR.WA01_KDM2B_KO 100 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 608 bp overlap

ChIP K-562 ENCSR782WRO.BMI1.K-562 271 bp overlap

BRD4 3 datasets

ChIP IMR-90_QUIES GSE74238.BRD4.IMR-90_QUIES 119 bp overlap

ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 432 bp overlap

ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 223 bp overlap

ChIP K562 ENCFF485TBL 84 bp overlap

CHD1 5 datasets

ChIP H1 ENCFF998XEK 650 bp overlap

ChIP HeLa-S3 ENCSR392EAA.CHD1.HeLa-S3 495 bp overlap

ChIP WA01 ENCSR000AQK.CHD1.WA01 464 bp overlap

ChIP WA01 ENCSR000AQK.CHD1.WA01 129 bp overlap

ChIP hMSC-TERT GSE89179.CHD1.hMSC-TERT 212 bp overlap

ChIP WA01 ENCSR000AVA.CHD7.WA01 253 bp overlap

CTBP2 3 datasets

ChIP H1 ENCFF329MAX 591 bp overlap

ChIP H1 ENCFF329MAX 182 bp overlap

ChIP WA01 ENCSR000EUO.CTBP2.WA01 930 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF262VBH 251 bp overlap

ChIP HeLa-S3 ENCSR219MKK.DEK.HeLa-S3 119 bp overlap

ChIP ProEs GSE59087.EED.ProEs 70 bp overlap

EGR1 2 datasets

ChIP H1 ENCFF451BLH 261 bp overlap

ChIP WA01 ENCSR000BJA.EGR1.WA01 251 bp overlap

ChIP WA01 ERP002417.ELK1.WA01 143 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 175 bp overlap

ESRRA 2 datasets

Motif DE_12h DE_12h-ESRRA_MA0592.4 9 bp overlap

Motif ES_0h ES_0h-ESRRA_MA0592.4 9 bp overlap

ESRRB 2 datasets

Motif DE_12h DE_12h-ESRRB_MA0141.4 10 bp overlap

Motif ES_0h ES_0h-ESRRB_MA0141.4 10 bp overlap

ETV5::FOXO1 1 dataset

Motif DE_12h DE_12h-ETV5FOXO1_MA1947.2 10 bp overlap

EZH2 48 datasets

ChIP A673 ENCFF790MVL 54 bp overlap

ChIP A673 ENCFF790MVL 185 bp overlap

ChIP A673 ENCFF955JRZ 126 bp overlap

ChIP A673 ENCFF955JRZ 212 bp overlap

ChIP A673 ENCFF955JRZ 148 bp overlap

ChIP B-cell ENCSR000AUZ.EZH2.B-cell 411 bp overlap

ChIP B-cell ENCSR000AUZ.EZH2.B-cell 265 bp overlap

ChIP DND41 ENCSR000ASW.EZH2.DND41 239 bp overlap

ChIP GM23248 ENCFF404ZHM 564 bp overlap

ChIP GM23248 ENCFF404ZHM 352 bp overlap

ChIP GM23248 ENCFF506FWX 445 bp overlap

ChIP GM23248 ENCFF506FWX 357 bp overlap

ChIP GM23338 ENCFF613YON 442 bp overlap

ChIP GM23338 ENCFF613YON 343 bp overlap

ChIP H1 ENCFF232NZA 1031 bp overlap

ChIP HUVEC-C GSE109625.EZH2.HUVEC-C 638 bp overlap

ChIP HUVEC-C_VEGF_12h GSE109625.EZH2.HUVEC-C_VEGF_12h 546 bp overlap

ChIP HUVEC-C_VEGF_1h GSE109625.EZH2.HUVEC-C_VEGF_1h 496 bp overlap

ChIP HUVEC-C_VEGF_4h GSE109625.EZH2.HUVEC-C_VEGF_4h 616 bp overlap

ChIP LNCaP-abl GSE39459.EZH2.LNCaP-abl 181 bp overlap

ChIP LNCaP-abl GSE39459.EZH2.LNCaP-abl 265 bp overlap

ChIP PC-3 ENCFF928VSN 485 bp overlap

ChIP astrocyte ENCFF365JTP 196 bp overlap

ChIP astrocyte ENCFF365JTP 576 bp overlap

ChIP astrocyte ENCFF365JTP 477 bp overlap

ChIP dermal-fibroblast_Preneoplastic GSE126396.EZH2.dermal-fibroblast_Preneoplastic 1031 bp overlap

ChIP endothelial cell of umbilical vein ENCFF539AKL 700 bp overlap

ChIP endothelial cell of umbilical vein ENCFF539AKL 835 bp overlap

ChIP endothelial cell of umbilical vein ENCFF539AKL 343 bp overlap

ChIP fibroblast of dermis ENCFF029VZK 267 bp overlap

ChIP fibroblast of dermis ENCFF029VZK 501 bp overlap

ChIP fibroblast of dermis ENCFF029VZK 327 bp overlap

ChIP fibroblast of dermis ENCFF029VZK 532 bp overlap

ChIP fibroblast of lung ENCFF479BAW 605 bp overlap

ChIP hepatocyte ENCFF118DKH 194 bp overlap

ChIP hepatocyte ENCFF118DKH 357 bp overlap

ChIP hepatocyte ENCFF552DZB 1031 bp overlap

ChIP keratinocyte ENCFF070STK 611 bp overlap

ChIP keratinocyte ENCFF070STK 611 bp overlap

ChIP mammary epithelial cell ENCFF224GAI 391 bp overlap

ChIP mammary epithelial cell ENCFF224GAI 181 bp overlap

ChIP myotube ENCFF857GWB 471 bp overlap

ChIP neural ENCSR511CUH.EZH2.neural 587 bp overlap

ChIP neural ENCSR511CUH.EZH2.neural 245 bp overlap

ChIP neural cell ENCFF610EPB 235 bp overlap

ChIP neural progenitor cell ENCFF018MKA 635 bp overlap

ChIP neural progenitor cell ENCFF018MKA 385 bp overlap

ChIP neural progenitor cell ENCFF472NFV 1031 bp overlap

Esrrg 2 datasets

Motif DE_12h DE_12h-Esrrg_MA0643.2 9 bp overlap

Motif ES_0h ES_0h-Esrrg_MA0643.2 9 bp overlap

FIGLA 1 dataset

Motif ES_0h ES_0h-FIGLA_MA0820.2 6 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 672 bp overlap

ChIP DE DE-FOXA2-2 571 bp overlap

FOXK1 1 dataset

ChIP WTC11 ENCFF875IGU 391 bp overlap

FOXO1::ELK3 1 dataset

Motif DE_12h DE_12h-FOXO1ELK3_MA1955.2 13 bp overlap

FOXP1 2 datasets

ChIP H9 GSE31006.FOXP1.H9 257 bp overlap

ChIP H9 GSE31006.FOXP1.H9 171 bp overlap

Foxn1 1 dataset

Motif ES_0h ES_0h-Foxn1_MA1684.1 6 bp overlap

GABPA 2 datasets

ChIP WA01 ENCSR000BIW.GABPA.WA01 125 bp overlap

ChIP WA01 ENCSR000BIW.GABPA.WA01 128 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 643 bp overlap

ChIP DE DE-GATA4-2 705 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 261 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 485 bp overlap

ChIP DE DE-GATA6-2 801 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 365 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 670 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 442 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 107 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 689 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 678 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 442 bp overlap

GTF3C2 2 datasets

ChIP H9 GSE94418.GTF3C2.H9 94 bp overlap

ChIP H9 GSE94418.GTF3C2.H9 224 bp overlap

HDAC2 1 dataset

ChIP WA01 ENCSR000AVB.HDAC2.WA01 493 bp overlap

HNRNPH1 1 dataset

ChIP Hep-G2 ENCSR066FXN.HNRNPH1.Hep-G2 165 bp overlap

Motif DE_36h DE_36h-IRF3_MA1418.2 17 bp overlap

JARID2 9 datasets

ChIP AMIPS6 GSE48516.JARID2.AMIPS6 475 bp overlap

ChIP AMIPS8 GSE48516.JARID2.AMIPS8 245 bp overlap

ChIP EDOMIPS2 GSE48516.JARID2.EDOMIPS2 470 bp overlap

ChIP EDOMIPS2 GSE48516.JARID2.EDOMIPS2 208 bp overlap

ChIP MRC-5_IPS25 GSE48516.JARID2.MRC-5_IPS25 171 bp overlap

ChIP UTEIPS11 GSE48516.JARID2.UTEIPS11 321 bp overlap

ChIP UTEIPS4 GSE48516.JARID2.UTEIPS4 115 bp overlap

ChIP UTEIPS4 GSE48516.JARID2.UTEIPS4 227 bp overlap

ChIP UTEIPS7 GSE48516.JARID2.UTEIPS7 1031 bp overlap

ChIP ESC S24-ESC-d0-JUN-exp1 445 bp overlap

ChIP HUES-8 GSE109524.JUN.HUES-8 446 bp overlap

ChIP OCI-AML-3 GSE133516.KAT7.OCI-AML-3 396 bp overlap

KDM4A 3 datasets

ChIP H1 ENCFF078LED 245 bp overlap

ChIP H1 ENCFF078LED 662 bp overlap

ChIP WA01 ENCSR000AVC.KDM4A.WA01 367 bp overlap

Motif DE_12h DE_12h-KLF1_MA0493.3 8 bp overlap

KLF10 1 dataset

Motif DE_12h DE_12h-KLF10_MA1511.2 9 bp overlap

KLF14 1 dataset

Motif DE_12h DE_12h-KLF14_MA0740.2 9 bp overlap

Motif DE_12h DE_12h-KLF2_MA1515.2 8 bp overlap

Motif DE_12h DE_12h-KLF4_MA0039.5 8 bp overlap

Motif DE_12h DE_12h-KLF5_MA0599.1 10 bp overlap

MEIS1 1 dataset

Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap

ChIP DU145_CTR GSE135623.MTF2.DU145_CTR 1031 bp overlap

ChIP COG-N-415 GSE138295.MYCN.COG-N-415 217 bp overlap

MYOD1 1 dataset

Motif ES_0h ES_0h-MYOD1_MA0499.3 9 bp overlap

NANOG 1 dataset

ChIP WA01 ENCSR000BMT.NANOG.WA01 118 bp overlap

NELFE 1 dataset

ChIP K-562_HS GSE112379.NELFE.K-562_HS 184 bp overlap

Motif DE_12h DE_12h-NFIA_MA0670.2 6 bp overlap

Motif DE_12h DE_12h-NFIX_MA0671.2 6 bp overlap

NFKB1 2 datasets

ChIP L1236 GSE63736.NFKB1.L1236 93 bp overlap

ChIP L1236 GSE63736.NFKB1.L1236 535 bp overlap

NFKB2 2 datasets

ChIP L1236 GSE63736.NFKB2.L1236 69 bp overlap

ChIP L1236 GSE63736.NFKB2.L1236 355 bp overlap

NRF1 2 datasets

ChIP HeLa-S3 GSE108856.NRF1.HeLa-S3 407 bp overlap

ChIP HeLa-S3 GSE108856.NRF1.HeLa-S3 296 bp overlap

Nfat5 1 dataset

Motif DE_36h DE_36h-Nfat5_MA0606.3 8 bp overlap

Nfatc2 1 dataset

Motif DE_36h DE_36h-Nfatc2_MA0152.3 8 bp overlap

Nr5A2 2 datasets

Motif DE_12h DE_12h-Nr5A2_MA0505.3 9 bp overlap

Motif ES_0h ES_0h-Nr5A2_MA0505.3 9 bp overlap

PCGF2 2 datasets

ChIP NT2-D1 GSE101538.PCGF2.NT2-D1 748 bp overlap

ChIP fibroblast_OHT GSE55605.PCGF2.fibroblast_OHT 546 bp overlap

ChIP T-47D-A_E2_R5020 GSE80358.PGR.T-47D-A_E2_R5020 254 bp overlap

POLR2A 1 dataset

ChIP neural cell ENCFF604SPB 385 bp overlap

POU5F1 3 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 1031 bp overlap

ChIP WA01_3IL ERP004238.POU5F1.WA01_3IL 91 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 177 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 543 bp overlap

Ptf1A 1 dataset

Motif ES_0h ES_0h-Ptf1A_MA1620.2 8 bp overlap

RAD21 1 dataset

ChIP HUVEC-C_hypoxia GSE94872.RAD21.HUVEC-C_hypoxia 144 bp overlap

RBBP5 2 datasets

ChIP H1 ENCFF905HFL 671 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 634 bp overlap

ChIP SGBS GSE64233.RELA.SGBS 381 bp overlap

ChIP L1236 GSE63736.RELB.L1236 108 bp overlap

RING1 2 datasets

ChIP SYO-1_shCt GSE139053.RING1.SYO-1_shCt 336 bp overlap

ChIP SYO-1_shCt GSE139053.RING1.SYO-1_shCt 126 bp overlap

RNF2 3 datasets

ChIP H1 ENCFF239FFS 435 bp overlap

ChIP H1 ENCFF239FFS 400 bp overlap

ChIP K-562 ENCSR076YPO.RNF2.K-562 166 bp overlap

SAP30 1 dataset

ChIP WA01 ENCSR000ATR.SAP30.WA01 499 bp overlap

SIN3A 1 dataset

ChIP WA01 ENCSR000BIS.SIN3A.WA01 174 bp overlap

SMAD1 1 dataset

ChIP BG03 GSE36578.SMAD1.BG03 96 bp overlap

SMAD2-3 4 datasets

ChIP HUES-8 GSE109524.SMAD2-3.HUES-8 369 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 604 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 871 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 166 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 529 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 178 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 427 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 368 bp overlap

ChIP ESC S33-ESC-d0-SMAD2_3-exp2 496 bp overlap

SMARCA4 1 dataset

ChIP HS-SY-2_HA-tagged GSE108926.SMARCA4.HS-SY-2_HA-tagged 715 bp overlap

SMARCC1 4 datasets

ChIP ESC S25-ESC-d0-BAF155-exp1 373 bp overlap

ChIP ESC S25-ESC-d0-BAF155-exp1 167 bp overlap

ChIP HS-SY-2 GSE108025.SMARCC1.HS-SY-2 303 bp overlap

ChIP HS-SY-2 GSE108025.SMARCC1.HS-SY-2 173 bp overlap

SNAI2 1 dataset

Motif ES_0h ES_0h-SNAI2_MA0745.3 8 bp overlap

SNAI3 1 dataset

Motif ES_0h ES_0h-SNAI3_MA1559.2 9 bp overlap

ChIP H1 ENCFF263FUH 321 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 425 bp overlap

ChIP WTC11 ENCFF688PEU 501 bp overlap

SRSF1 1 dataset

ChIP Hep-G2 GSE120104.SRSF1.Hep-G2 93 bp overlap

ChIP SYO-1_shCt GSE139053.SS18.SYO-1_shCt 259 bp overlap

SS18-SSX 1 dataset

ChIP fibroblast_78aa-SSX-Tail GSE139053.SS18-SSX.fibroblast_78aa-SSX-Tail 155 bp overlap

SUZ12 7 datasets

ChIP H1 ENCFF881NFR 1031 bp overlap

ChIP K-562 ENCSR000AUC.SUZ12.K-562 179 bp overlap

ChIP NT2-D1 GSE101538.SUZ12.NT2-D1 413 bp overlap

ChIP NT2/D1 ENCFF574SXS 713 bp overlap

ChIP SYO-1_shCt GSE139053.SUZ12.SYO-1_shCt 107 bp overlap

ChIP SYO-1_shCt GSE139053.SUZ12.SYO-1_shCt 774 bp overlap

ChIP WA01 ENCSR000ATS.SUZ12.WA01 652 bp overlap

Smad4 1 dataset

Motif ES_0h ES_0h-Smad4_MA1153.2 7 bp overlap

Stat2 2 datasets

Motif DE_12h DE_12h-Stat2_MA1623.2 10 bp overlap

Motif DE_36h DE_36h-Stat2_MA1623.2 10 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 278 bp overlap

ChIP liver ENCSR016BMM.TAF1.liver 335 bp overlap

ChIP H1 ENCFF859IIO 377 bp overlap

ChIP HeLa-S3 ENCFF715NNJ 381 bp overlap

ChIP HeLa-S3 ENCFF715NNJ 204 bp overlap

ChIP HeLa-S3 ENCSR000EDD.TBP.HeLa-S3 134 bp overlap

ChIP HeLa-S3 ENCSR000EDD.TBP.HeLa-S3 395 bp overlap

ChIP WA01 ENCSR000ECB.TBP.WA01 191 bp overlap

TCF12 3 datasets

ChIP H1 ENCFF203EBH 251 bp overlap

ChIP H1 ENCFF203EBH 251 bp overlap

ChIP WA01 ENCSR000BIT.TCF12.WA01 902 bp overlap

TCF7L2 2 datasets

ChIP HeLa-S3 ENCFF673QAB 449 bp overlap

ChIP HeLa-S3 ENCSR000EVE.TCF7L2.HeLa-S3 246 bp overlap

TFAP2C 1 dataset

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 52 bp overlap

ChIP SUIT-2 GSE115461.TP63.SUIT-2 179 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 320 bp overlap

ChIP liver ENCFF515BWJ 565 bp overlap

ChIP liver ENCFF515BWJ 565 bp overlap

ChIP liver ENCSR994YLZ.YY1.liver 166 bp overlap

ChIP liver ENCSR994YLZ.YY1.liver 264 bp overlap

ZBTB7A 1 dataset

ChIP K-562 ENCSR000BME.ZBTB7A.K-562 97 bp overlap

ZEB1 2 datasets

Motif ES_0h ES_0h-ZEB1_MA0103.4 6 bp overlap

ChIP neuron_bipolar_doxy_4d ENCSR418KUS.ZEB1.neuron_bipolar_doxy_4d 228 bp overlap

ZFP36 1 dataset

ChIP K-562 ENCSR776CYN.ZFP36.K-562 150 bp overlap

ZNF506 1 dataset

ChIP HEK293T GSE78099.ZNF506.HEK293T 120 bp overlap

ZNF677 1 dataset

Motif ES_0h ES_0h-ZNF677_MA2101.1 12 bp overlap

ZNF740 1 dataset

Motif DE_12h DE_12h-ZNF740_MA0753.3 10 bp overlap

ZNF766 1 dataset

Motif DE_12h DE_12h-ZNF766_MA2098.1 9 bp overlap

ZNF865 1 dataset

ChIP HepG2 ENCFF472KAQ 331 bp overlap

Zfp809 1 dataset

Motif DE_12h DE_12h-Zfp809_MA2125.1 9 bp overlap