This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for BMI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BMI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BMI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:22,228,979–22,229,717 | 92.1 kb | Distal (>10kb) Multiome | 978 | |
| chr10:22,243,000–22,244,484 | 77.6 kb | Distal (>10kb) Multiome | 178 | |
| chr10:22,315,958–22,317,121 | 5.1 kb | Proximal (<10kb) Multiome | 907 | |
| chr10:22,320,392–22,321,837 | 466 bp | At TSS Multiome | 685 | |
| chr10:22,321,932–22,322,482 | 474 bp | At TSS | 231 | |
| chr10:22,325,314–22,326,207 | 4.3 kb | Proximal (<10kb) Multiome | 543 | |
| chr10:22,333,913–22,337,163 | 15.2 kb | Distal (>10kb) Multiome | 477 | |
| chr10:22,340,282–22,341,538 | 19.3 kb | Distal (>10kb) Multiome | 773 | |
| chr10:22,436,581–22,437,900 | 115.6 kb | Distal (>10kb) Multiome | 649 | |
| chr10:22,513,530–22,514,377 | 192.5 kb | Distal (>10kb) Multiome | 268 |
Genomic view of the BMI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.