The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PCGF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCGF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCGF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:38,453,611–38,454,219 | 294.5 kb | Distal (>10kb) Multiome | 168 | |
| chr17:38,509,961–38,510,926 | 237.8 kb | Distal (>10kb) Multiome | 409 | |
| chr17:38,558,106–38,558,652 | 190.1 kb | Distal (>10kb) Multiome | 631 | |
| chr17:38,559,205–38,559,900 | 188.7 kb | Distal (>10kb) Multiome | 598 | |
| chr17:38,572,553–38,573,232 | 175.4 kb | Distal (>10kb) Multiome | 231 | |
| chr17:38,604,448–38,605,250 | 143.5 kb | Distal (>10kb) Multiome | 375 | |
| chr17:38,605,359–38,606,888 | 141.9 kb | Distal (>10kb) Multiome | 781 | |
| chr17:38,609,172–38,610,061 | 138.7 kb | Distal (>10kb) Multiome | 229 | |
| chr17:38,673,658–38,675,315 | 73.4 kb | Distal (>10kb) Multiome | 847 | |
| chr17:38,701,857–38,703,072 | 46.0 kb | Distal (>10kb) Multiome | 907 | |
| chr17:38,703,568–38,704,668 | 44.4 kb | Distal (>10kb) Multiome | 955 | |
| chr17:38,704,725–38,707,220 | 43.0 kb | Distal (>10kb) Multiome | 784 | |
| chr17:38,718,492–38,719,127 | 29.6 kb | Distal (>10kb) Multiome | 268 | |
| chr17:38,719,228–38,720,635 | 28.2 kb | Distal (>10kb) Multiome | 290 | |
| chr17:38,729,824–38,730,713 | 18.2 kb | Distal (>10kb) Multiome | 794 | |
| chr17:38,747,498–38,750,334 | 1.5 kb | Proximal (<10kb) Multiome | 914 | |
| chr17:38,751,747–38,753,201 | 3.4 kb | Proximal (<10kb) Multiome | 986 | |
| chr17:38,789,155–38,789,604 | 41.0 kb | Distal (>10kb) Multiome | 144 | |
| chr17:38,798,912–38,800,293 | 51.5 kb | Distal (>10kb) Multiome | 966 | |
| chr17:38,824,673–38,825,720 | 76.9 kb | Distal (>10kb) Multiome | 978 | |
| chr17:38,853,382–38,854,144 | 105.4 kb | Distal (>10kb) Multiome | 1047 | |
| chr17:38,867,391–38,868,381 | 119.3 kb | Distal (>10kb) Multiome | 640 | |
| chr17:38,869,253–38,871,194 | 121.4 kb | Distal (>10kb) Multiome | 1074 | |
| chr17:38,900,769–38,901,637 | 152.9 kb | Distal (>10kb) Multiome | 370 | |
| chr17:38,967,321–38,967,861 | 219.2 kb | Distal (>10kb) Multiome | 219 | |
| chr17:39,011,896–39,012,455 | 263.8 kb | Distal (>10kb) Multiome | 81 |
Genomic view of the PCGF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.