This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RING1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RING1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RING1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:32,952,883–32,953,496 | 255.3 kb | Distal (>10kb) Multiome | 366 | |
| chr6:32,967,972–32,971,214 | 239.7 kb | Distal (>10kb) Multiome | 1227 | |
| chr6:32,971,467–32,973,408 | 236.5 kb | Distal (>10kb) Multiome | 1115 | |
| chr6:33,009,348–33,009,899 | 198.8 kb | Distal (>10kb) Multiome | 184 | |
| chr6:33,080,635–33,081,087 | 127.8 kb | Distal (>10kb) Multiome | 141 | |
| chr6:33,161,505–33,162,100 | 46.8 kb | Distal (>10kb) Multiome | 589 | |
| chr6:33,199,801–33,201,289 | 7.8 kb | Proximal (<10kb) Multiome | 1049 | |
| chr6:33,204,263–33,205,422 | 3.9 kb | Proximal (<10kb) Multiome | 762 | |
| chr6:33,207,796–33,208,014 | 484 bp | At TSS | 349 | |
| chr6:33,208,069–33,208,990 | 99 bp | At TSS Multiome | 858 | |
| chr6:33,248,132–33,249,983 | 39.8 kb | Distal (>10kb) Multiome | 961 | |
| chr6:33,271,370–33,272,508 | 63.5 kb | Distal (>10kb) Multiome | 1058 | |
| chr6:33,276,685–33,277,905 | 68.9 kb | Distal (>10kb) Multiome | 807 | |
| chr6:33,288,941–33,289,881 | 80.9 kb | Distal (>10kb) Multiome | 701 | |
| chr6:33,297,445–33,300,232 | 89.4 kb | Distal (>10kb) Multiome | 1095 | |
| chr6:33,312,436–33,314,207 | 104.4 kb | Distal (>10kb) Multiome | 795 | |
| chr6:33,317,189–33,318,504 | 109.4 kb | Distal (>10kb) Multiome | 649 | |
| chr6:33,322,636–33,323,832 | 114.6 kb | Distal (>10kb) Multiome | 941 | |
| chr6:33,346,609–33,347,126 | 138.3 kb | Distal (>10kb) Multiome | 37 | |
| chr6:33,390,888–33,392,247 | 183.1 kb | Distal (>10kb) Multiome | 993 | |
| chr6:33,409,936–33,411,502 | 202.0 kb | Distal (>10kb) Multiome | 977 | |
| chr6:33,417,606–33,419,249 | 209.8 kb | Distal (>10kb) Multiome | 973 | |
| chr6:33,419,793–33,420,532 | 211.7 kb | Distal (>10kb) Multiome | 162 | |
| chr6:33,425,590–33,426,362 | 217.4 kb | Distal (>10kb) Multiome | 665 | |
| chr6:33,431,024–33,432,096 | 222.7 kb | Distal (>10kb) Multiome | 337 | |
| chr6:33,454,074–33,454,852 | 246.0 kb | Distal (>10kb) Multiome | 906 |
Genomic view of the RING1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.