The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for FECH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FECH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FECH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:57,353,121–57,354,452 | 232.7 kb | Distal (>10kb) Multiome | 583 | |
| chr18:57,427,416–57,429,100 | 158.8 kb | Distal (>10kb) Multiome | 283 | |
| chr18:57,430,302–57,431,333 | 156.0 kb | Distal (>10kb) Multiome | 103 | |
| chr18:57,434,697–57,437,032 | 151.4 kb | Distal (>10kb) Multiome | 598 | |
| chr18:57,437,281–57,438,885 | 148.8 kb | Distal (>10kb) Multiome | 551 | |
| chr18:57,447,194–57,447,641 | 139.3 kb | Distal (>10kb) Multiome | 254 | |
| chr18:57,586,255–57,586,993 | 71 bp | At TSS Multiome | 659 | |
| chr18:57,595,355–57,595,786 | 8.6 kb | Proximal (<10kb) | 64 | |
| chr18:57,621,352–57,622,282 | 35.1 kb | Distal (>10kb) Multiome | 848 | |
| chr18:57,629,956–57,630,747 | 43.6 kb | Distal (>10kb) Multiome | 808 | |
| chr18:57,696,040–57,696,825 | 109.7 kb | Distal (>10kb) Multiome | 32 | |
| chr18:57,696,903–57,697,716 | 110.7 kb | Distal (>10kb) Multiome | 39 | |
| chr18:57,698,529–57,699,223 | 112.0 kb | Distal (>10kb) Multiome | 219 | |
| chr18:57,797,314–57,797,787 | 210.8 kb | Distal (>10kb) Multiome | 429 | |
| chr18:57,802,264–57,804,080 | 216.7 kb | Distal (>10kb) Multiome | 584 | |
| chr18:57,856,110–57,857,036 | 269.9 kb | Distal (>10kb) Multiome | 51 |
Genomic view of the FECH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.