The protein encoded by this gene is a nuclear receptor that is most closely related to the estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcription cofactors to regulate the expression of most genes involved in cellular energy production as well as in the process of mitochondrial biogenesis. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq, Jun 2019]
Transcription factors with Perturb-seq knockdown data for ESRRA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ESRRA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ESRRA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:64,028,126–64,028,898 | 276.9 kb | Distal (>10kb) Multiome | 168 | |
| chr11:64,165,638–64,166,698 | 139.3 kb | Distal (>10kb) Multiome | 811 | |
| chr11:64,184,927–64,186,817 | 119.6 kb | Distal (>10kb) Multiome | 1091 | |
| chr11:64,225,548–64,226,862 | 79.3 kb | Distal (>10kb) Multiome | 776 | |
| chr11:64,230,074–64,231,130 | 75.0 kb | Distal (>10kb) Multiome | 715 | |
| chr11:64,233,950–64,235,296 | 71.0 kb | Distal (>10kb) Multiome | 590 | |
| chr11:64,240,398–64,242,687 | 64.2 kb | Distal (>10kb) Multiome | 982 | |
| chr11:64,246,274–64,248,065 | 58.4 kb | Distal (>10kb) Multiome | 802 | |
| chr11:64,250,699–64,251,842 | 54.1 kb | Distal (>10kb) Multiome | 498 | |
| chr11:64,268,509–64,270,920 | 35.4 kb | Distal (>10kb) Multiome | 1093 | |
| chr11:64,271,352–64,271,994 | 33.9 kb | Distal (>10kb) Multiome | 595 | |
| chr11:64,284,095–64,286,666 | 19.8 kb | Distal (>10kb) Multiome | 807 | |
| chr11:64,300,129–64,301,268 | 4.5 kb | Proximal (<10kb) Multiome | 591 | |
| chr11:64,304,032–64,307,072 | 856 bp | At TSS Multiome | 994 | |
| chr11:64,316,954–64,319,418 | 13.5 kb | Distal (>10kb) Multiome | 1039 | |
| chr11:64,340,711–64,341,211 | 35.4 kb | Distal (>10kb) Multiome | 212 | |
| chr11:64,342,083–64,343,227 | 37.2 kb | Distal (>10kb) Multiome | 543 | |
| chr11:64,358,792–64,359,751 | 53.6 kb | Distal (>10kb) Multiome | 577 | |
| chr11:64,448,870–64,449,995 | 143.5 kb | Distal (>10kb) Multiome | 490 |
Genomic view of the ESRRA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.