This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WDR7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:55,322,133–55,322,873 | 1328.9 kb | Distal (>10kb) Multiome HiCAR | 382 | |
| chr18:56,637,964–56,639,090 | 12.6 kb | Distal (>10kb) Multiome | 800 | |
| chr18:56,647,924–56,648,674 | 3.0 kb | Proximal (<10kb) Multiome | 57 | |
| chr18:56,650,881–56,651,893 | 4 bp | At TSS Multiome | 834 | |
| chr18:56,913,889–56,914,807 | 263.0 kb | Distal (>10kb) Multiome | 134 | |
| chr18:57,430,302–57,431,333 | 779.4 kb | Distal (>10kb) Multiome HiCAR | 103 | |
| chr18:57,434,697–57,437,032 | 784.0 kb | Distal (>10kb) Multiome HiCAR | 598 | |
| chr18:57,437,281–57,438,885 | 786.6 kb | Distal (>10kb) Multiome HiCAR | 551 |
Genomic view of the WDR7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.