Transcription factors with Perturb-seq knockdown data for ATP8B1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP8B1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP8B1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:57,353,121–57,354,452 | 276.3 kb | Distal (>10kb) Multiome | 583 | |
| chr18:57,427,416–57,429,100 | 202.4 kb | Distal (>10kb) Multiome | 283 | |
| chr18:57,430,302–57,431,333 | 199.6 kb | Distal (>10kb) Multiome | 103 | |
| chr18:57,434,697–57,437,032 | 195.0 kb | Distal (>10kb) Multiome | 598 | |
| chr18:57,437,281–57,438,885 | 192.4 kb | Distal (>10kb) Multiome | 551 | |
| chr18:57,447,194–57,447,641 | 182.9 kb | Distal (>10kb) Multiome | 254 | |
| chr18:57,586,255–57,586,993 | 43.7 kb | Distal (>10kb) Multiome | 659 | |
| chr18:57,621,352–57,622,282 | 8.5 kb | Proximal (<10kb) Multiome | 848 | |
| chr18:57,629,956–57,630,747 | 31 bp | At TSS Multiome | 808 | |
| chr18:57,696,040–57,696,825 | 66.1 kb | Distal (>10kb) Multiome | 32 | |
| chr18:57,696,903–57,697,716 | 67.1 kb | Distal (>10kb) Multiome | 39 | |
| chr18:57,698,529–57,699,223 | 68.4 kb | Distal (>10kb) Multiome | 219 | |
| chr18:57,797,314–57,797,787 | 167.2 kb | Distal (>10kb) Multiome | 429 | |
| chr18:57,802,264–57,804,080 | 173.0 kb | Distal (>10kb) Multiome HiCAR | 584 | |
| chr18:57,856,110–57,857,036 | 226.3 kb | Distal (>10kb) Multiome HiCAR | 51 |
Genomic view of the ATP8B1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.