This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for NFIA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFIA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFIA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:60,886,582–60,887,519 | 195.4 kb | Distal (>10kb) Multiome | 243 | |
| chr1:61,005,658–61,006,366 | 76.7 kb | Distal (>10kb) Multiome | 141 | |
| chr1:61,042,817–61,044,207 | 39.3 kb | Distal (>10kb) Multiome | 497 | |
| chr1:61,049,676–61,051,397 | 32.4 kb | Distal (>10kb) Multiome | 791 | |
| chr1:61,076,598–61,077,468 | 5.5 kb | Proximal (<10kb) Multiome | 791 | |
| chr1:61,077,759–61,078,262 | 4.4 kb | Proximal (<10kb) Multiome | 483 | |
| chr1:61,079,925–61,080,167 | 2.4 kb | Proximal (<10kb) | 517 | |
| chr1:61,081,616–61,083,872 | 231 bp | At TSS Multiome | 683 |
Genomic view of the NFIA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.