ONECUT2

one cut homeobox 2 | OC-2

This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008]

Member of: DE-4 Developmental clusters: GC7

Biological processes 16 terms

DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)animal organ morphogenesis (GO:0009887)chromatin (GO:0000785)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific double-stranded DNA binding (GO:1990837)

Expression (TPM)

TFs regulating ONECUT2 0 TFs

Transcription factors with Perturb-seq knockdown data for ONECUT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ONECUT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ONECUT2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ONECUT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr18:57,134,464–57,135,373	300.5 kb	Distal (>10kb) Multiome HiCAR	267
chr18:57,206,590–57,207,847	228.2 kb	Distal (>10kb) Multiome HiCAR	126
chr18:57,353,121–57,354,452	81.3 kb	Distal (>10kb) Multiome	583
chr18:57,427,416–57,429,100	7.4 kb	Proximal (<10kb) Multiome	283
chr18:57,430,302–57,431,333	4.6 kb	Proximal (<10kb) Multiome	103
chr18:57,434,697–57,437,032	56 bp	At TSS Multiome	598
chr18:57,437,281–57,438,885	2.6 kb	Proximal (<10kb) Multiome	551
chr18:57,438,989–57,439,138	3.6 kb	Proximal (<10kb)	64
chr18:57,439,545–57,440,223	4.2 kb	Proximal (<10kb)	59
chr18:57,440,425–57,441,156	5.1 kb	Proximal (<10kb)	108
chr18:57,441,272–57,441,712	5.9 kb	Proximal (<10kb)	147
chr18:57,447,194–57,447,641	12.1 kb	Distal (>10kb) Multiome	254
chr18:57,586,255–57,586,993	151.3 kb	Distal (>10kb) Multiome	659
chr18:57,621,352–57,622,282	186.5 kb	Distal (>10kb) Multiome	848
chr18:57,629,956–57,630,747	194.9 kb	Distal (>10kb) Multiome	808
chr18:57,696,040–57,696,825	261.1 kb	Distal (>10kb) Multiome	32
chr18:57,696,903–57,697,716	262.0 kb	Distal (>10kb) Multiome	39
chr18:57,698,529–57,699,223	263.4 kb	Distal (>10kb) Multiome	219
chr18:59,219,767–59,220,751	1784.9 kb	Distal (>10kb) Multiome HiCAR	135
chr18:59,265,207–59,265,918	1830.2 kb	Distal (>10kb) Multiome HiCAR	139
chr18:59,268,665–59,269,734	1833.9 kb	Distal (>10kb) Multiome HiCAR	312
chr18:59,272,354–59,274,393	1838.1 kb	Distal (>10kb) Multiome HiCAR	271

Genome Browser

Genomic view of the ONECUT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.