NRF1

nuclear respiratory factor 1 | ALPHA-PAL, EWG

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

Member of: DE-2 DE-2.1

Biological processes 19 terms

DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)extracellular exosome (GO:0070062)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)

TFs regulating NRF1 0 TFs

Transcription factors with Perturb-seq knockdown data for NRF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NRF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NRF1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NRF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:129,433,659–129,435,261	177.4 kb	Distal (>10kb) Multiome	770
chr7:129,453,732–129,454,848	157.3 kb	Distal (>10kb) Multiome	197
chr7:129,502,098–129,503,287	109.3 kb	Distal (>10kb) Multiome	480
chr7:129,607,861–129,608,034	3.7 kb	Proximal (<10kb)	77
chr7:129,611,327–129,612,516	1 bp	At TSS Multiome	882
chr7:129,775,743–129,776,961	164.9 kb	Distal (>10kb) Multiome	77
chr7:129,778,637–129,782,868	168.6 kb	Distal (>10kb) Multiome	821
chr7:129,824,642–129,826,481	214.2 kb	Distal (>10kb) Multiome	809
chr7:129,829,901–129,830,704	218.6 kb	Distal (>10kb) Multiome	440

Genome Browser

Genomic view of the NRF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.