Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF865. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF865 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF865, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:54,430,381–54,431,285 | 1174.7 kb | Distal (>10kb) Multiome HiCAR | 240 | |
| chr19:55,338,676–55,340,358 | 266.1 kb | Distal (>10kb) Multiome | 882 | |
| chr19:55,340,675–55,341,535 | 264.3 kb | Distal (>10kb) Multiome | 368 | |
| chr19:55,353,720–55,354,487 | 251.5 kb | Distal (>10kb) Multiome | 297 | |
| chr19:55,369,099–55,370,447 | 235.6 kb | Distal (>10kb) Multiome | 383 | |
| chr19:55,383,539–55,384,553 | 221.8 kb | Distal (>10kb) Multiome | 374 | |
| chr19:55,384,697–55,386,560 | 219.9 kb | Distal (>10kb) Multiome | 903 | |
| chr19:55,406,950–55,408,675 | 197.6 kb | Distal (>10kb) Multiome | 965 | |
| chr19:55,452,738–55,453,308 | 152.6 kb | Distal (>10kb) Multiome | 339 | |
| chr19:55,460,784–55,462,230 | 143.8 kb | Distal (>10kb) Multiome | 947 | |
| chr19:55,476,048–55,477,307 | 129.0 kb | Distal (>10kb) Multiome | 1007 | |
| chr19:55,484,846–55,485,682 | 120.5 kb | Distal (>10kb) Multiome | 594 | |
| chr19:55,503,638–55,504,310 | 101.6 kb | Distal (>10kb) Multiome | 710 | |
| chr19:55,516,768–55,517,459 | 88.5 kb | Distal (>10kb) Multiome | 583 | |
| chr19:55,536,923–55,537,366 | 68.5 kb | Distal (>10kb) Multiome | 180 | |
| chr19:55,549,822–55,550,343 | 55.6 kb | Distal (>10kb) Multiome | 396 | |
| chr19:55,580,080–55,581,090 | 24.8 kb | Distal (>10kb) Multiome | 718 | |
| chr19:55,585,644–55,586,314 | 19.8 kb | Distal (>10kb) Multiome | 370 | |
| chr19:55,586,698–55,587,594 | 18.3 kb | Distal (>10kb) Multiome | 463 | |
| chr19:55,598,551–55,600,991 | 5.2 kb | Proximal (<10kb) Multiome | 1018 | |
| chr19:55,604,520–55,606,690 | 307 bp | At TSS Multiome | 820 | |
| chr19:55,623,637–55,625,055 | 18.9 kb | Distal (>10kb) Multiome | 650 | |
| chr19:55,640,091–55,641,769 | 35.4 kb | Distal (>10kb) Multiome | 821 | |
| chr19:55,642,197–55,644,356 | 37.9 kb | Distal (>10kb) Multiome | 884 | |
| chr19:55,647,711–55,648,342 | 42.4 kb | Distal (>10kb) Multiome | 671 | |
| chr19:55,652,138–55,653,078 | 46.8 kb | Distal (>10kb) Multiome | 105 | |
| chr19:55,653,199–55,656,056 | 49.0 kb | Distal (>10kb) Multiome | 1123 | |
| chr19:55,674,767–55,675,613 | 69.5 kb | Distal (>10kb) Multiome | 765 |
Genomic view of the ZNF865 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.