RELB
RELB proto-oncogene, NF-kB subunit | REL-B

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in several cellular components, including centrosome; chromatin; and nucleoplasm. Part of nucleus and transcription repressor complex. Implicated in breast cancer and immunodeficiency 53. Biomarker of breast cancer and transitional cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 43 terms
DNA binding (GO:0003677)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)canonical NF-kappaB signal transduction (GO:0007249)cellular response to osmotic stress (GO:0071470)centrosome (GO:0005813)centrosome (GO:0005813)chromatin (GO:0000785)chromatin (GO:0000785)circadian regulation of gene expression (GO:0032922)circadian regulation of gene expression (GO:0032922)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)identical protein binding (GO:0042802)inflammatory response (GO:0006954)innate immune response (GO:0045087)lymphocyte differentiation (GO:0030098)lymphocyte differentiation (GO:0030098)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of interferon-beta production (GO:0032688)non-canonical NF-kappaB signal transduction (GO:0038061)non-canonical NF-kappaB signal transduction (GO:0038061)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein kinase binding (GO:0019901)protein-containing complex (GO:0032991)regulation of DNA-templated transcription (GO:0006355)regulation of gene expression (GO:0010468)response to cytokine (GO:0034097)synapse (GO:0045202)transcription repressor complex (GO:0017053)
Expression (TPM)
RELB — as a Regulated Gene

TFs regulating RELB 0 TFs

Transcription factors with Perturb-seq knockdown data for RELB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RELB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RELB

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RELB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:44,747,085–44,747,789 253.9 kb Distal (>10kb) Multiome 653
chr19:44,757,112–44,758,480 244.0 kb Distal (>10kb) Multiome 209
chr19:44,758,633–44,759,104 242.5 kb Distal (>10kb) Multiome 80
chr19:44,770,589–44,771,108 230.7 kb Distal (>10kb) Multiome 367
chr19:44,777,671–44,778,314 223.6 kb Distal (>10kb) Multiome 353
chr19:44,800,231–44,800,829 200.8 kb Distal (>10kb) Multiome 508
chr19:44,807,965–44,809,338 193.3 kb Distal (>10kb) Multiome 652
chr19:44,844,448–44,848,668 156.7 kb Distal (>10kb) Multiome 1047
chr19:44,890,209–44,891,796 110.6 kb Distal (>10kb) Multiome 952
chr19:44,903,686–44,904,241 97.7 kb Distal (>10kb) Multiome 666
chr19:44,905,114–44,907,037 94.8 kb Distal (>10kb) Multiome 645
chr19:44,913,546–44,915,671 86.3 kb Distal (>10kb) Multiome 587
chr19:44,926,693–44,927,388 74.3 kb Distal (>10kb) Multiome 277
chr19:44,954,641–44,955,824 46.2 kb Distal (>10kb) Multiome 835
chr19:45,001,031–45,002,639 78 bp At TSS Multiome 694
chr19:45,038,879–45,039,566 37.7 kb Distal (>10kb) Multiome 800
chr19:45,075,125–45,076,814 75.1 kb Distal (>10kb) Multiome 710
chr19:45,078,897–45,080,647 78.7 kb Distal (>10kb) Multiome 1012
chr19:45,091,042–45,093,574 91.5 kb Distal (>10kb) Multiome 959
chr19:45,177,803–45,179,711 177.0 kb Distal (>10kb) Multiome 899
chr19:45,234,200–45,234,822 233.1 kb Distal (>10kb) Multiome 105
chr19:45,250,821–45,251,491 249.8 kb Distal (>10kb) Multiome 397

Genome Browser

Genomic view of the RELB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:44,737,085 – 45,261,491
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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