Enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity and identical protein binding activity. Involved in several processes, including ganglioside biosynthetic process; glycoprotein metabolic process; and sialylation. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ST8SIA3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST8SIA3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST8SIA3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:57,121,407–57,122,243 | 230.7 kb | Distal (>10kb) Multiome | 172 | |
| chr18:57,352,243–57,352,934 | at TSS | At TSS | 83 | |
| chr18:57,353,121–57,354,452 | 1.5 kb | Proximal (<10kb) Multiome | 583 | |
| chr18:57,427,416–57,429,100 | 75.4 kb | Distal (>10kb) Multiome | 283 | |
| chr18:57,430,302–57,431,333 | 78.0 kb | Distal (>10kb) Multiome | 103 | |
| chr18:57,434,697–57,437,032 | 82.8 kb | Distal (>10kb) Multiome | 598 | |
| chr18:57,437,281–57,438,885 | 85.5 kb | Distal (>10kb) Multiome | 551 | |
| chr18:57,447,194–57,447,641 | 94.9 kb | Distal (>10kb) Multiome | 254 | |
| chr18:57,586,255–57,586,993 | 234.1 kb | Distal (>10kb) Multiome | 659 | |
| chr18:57,621,352–57,622,282 | 269.3 kb | Distal (>10kb) Multiome | 848 | |
| chr18:57,629,956–57,630,747 | 277.8 kb | Distal (>10kb) Multiome | 808 |
Genomic view of the ST8SIA3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.