Transcription factors with Perturb-seq knockdown data for ENSG00000267787. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000267787 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000267787, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:57,427,416–57,429,100 | 268.0 kb | Distal (>10kb) Multiome | 283 | |
| chr18:57,430,302–57,431,333 | 265.2 kb | Distal (>10kb) Multiome | 103 | |
| chr18:57,434,697–57,437,032 | 260.6 kb | Distal (>10kb) Multiome | 598 | |
| chr18:57,437,281–57,438,885 | 258.0 kb | Distal (>10kb) Multiome | 551 | |
| chr18:57,447,194–57,447,641 | 248.5 kb | Distal (>10kb) Multiome | 254 | |
| chr18:57,586,255–57,586,993 | 109.3 kb | Distal (>10kb) Multiome | 659 | |
| chr18:57,621,352–57,622,282 | 74.1 kb | Distal (>10kb) Multiome | 848 | |
| chr18:57,629,956–57,630,747 | 65.6 kb | Distal (>10kb) Multiome | 808 | |
| chr18:57,696,040–57,696,825 | 504 bp | At TSS Multiome | 32 | |
| chr18:57,696,903–57,697,716 | 1.5 kb | Proximal (<10kb) Multiome | 39 | |
| chr18:57,698,529–57,699,223 | 2.8 kb | Proximal (<10kb) Multiome | 219 | |
| chr18:57,797,314–57,797,787 | 101.6 kb | Distal (>10kb) Multiome | 429 | |
| chr18:57,802,264–57,804,080 | 107.4 kb | Distal (>10kb) Multiome | 584 | |
| chr18:57,856,110–57,857,036 | 160.7 kb | Distal (>10kb) Multiome | 51 |
Genomic view of the ENSG00000267787 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.