This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for ELK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:47,361,756–47,362,456 | 288.4 kb | Distal (>10kb) Multiome | 297 | |
| chrX:47,381,691–47,382,470 | 268.4 kb | Distal (>10kb) Multiome | 17 | |
| chrX:47,482,474–47,483,311 | 167.8 kb | Distal (>10kb) Multiome | 573 | |
| chrX:47,523,425–47,523,870 | 127.0 kb | Distal (>10kb) Multiome | 403 | |
| chrX:47,556,126–47,556,602 | 94.3 kb | Distal (>10kb) Multiome | 278 | |
| chrX:47,560,759–47,561,636 | 89.3 kb | Distal (>10kb) Multiome | 638 | |
| chrX:47,619,457–47,620,174 | 30.6 kb | Distal (>10kb) Multiome | 643 | |
| chrX:47,623,578–47,624,031 | 26.7 kb | Distal (>10kb) Multiome | 183 | |
| chrX:47,650,269–47,651,363 | 245 bp | At TSS Multiome | 552 | |
| chrX:47,658,568–47,659,484 | 8.5 kb | Proximal (<10kb) Multiome | 753 | |
| chrX:47,836,213–47,837,023 | 186.1 kb | Distal (>10kb) Multiome | 544 |
Genomic view of the ELK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.