The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for KAT7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KAT7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KAT7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:49,494,780–49,495,773 | 293.5 kb | Distal (>10kb) Multiome | 386 | |
| chr17:49,496,269–49,496,902 | 292.1 kb | Distal (>10kb) Multiome | 440 | |
| chr17:49,497,462–49,497,966 | 290.8 kb | Distal (>10kb) Multiome | 280 | |
| chr17:49,508,179–49,508,962 | 280.1 kb | Distal (>10kb) Multiome | 380 | |
| chr17:49,556,195–49,556,772 | 232.2 kb | Distal (>10kb) Multiome | 636 | |
| chr17:49,567,907–49,568,549 | 220.6 kb | Distal (>10kb) Multiome | 623 | |
| chr17:49,569,780–49,570,501 | 218.5 kb | Distal (>10kb) Multiome | 893 | |
| chr17:49,575,427–49,577,397 | 212.0 kb | Distal (>10kb) Multiome | 657 | |
| chr17:49,677,242–49,678,492 | 110.6 kb | Distal (>10kb) Multiome | 1110 | |
| chr17:49,707,638–49,708,519 | 80.4 kb | Distal (>10kb) Multiome | 927 | |
| chr17:49,763,285–49,764,743 | 24.4 kb | Distal (>10kb) Multiome | 768 | |
| chr17:49,788,330–49,789,442 | 152 bp | At TSS Multiome | 1068 | |
| chr17:49,816,106–49,816,291 | 1.1 kb | Proximal (<10kb) | 103 | |
| chr17:49,851,098–49,852,060 | 63.2 kb | Distal (>10kb) Multiome | 614 | |
| chr17:49,865,367–49,866,210 | 77.2 kb | Distal (>10kb) Multiome | 213 | |
| chr17:49,880,287–49,880,820 | 91.9 kb | Distal (>10kb) Multiome | 493 | |
| chr17:49,910,218–49,910,854 | 121.9 kb | Distal (>10kb) Multiome | 230 | |
| chr17:49,968,328–49,969,629 | 180.4 kb | Distal (>10kb) Multiome | 702 | |
| chr17:49,993,266–49,993,947 | 204.9 kb | Distal (>10kb) Multiome | 222 | |
| chr17:49,994,638–49,995,383 | 206.5 kb | Distal (>10kb) Multiome | 281 | |
| chr17:49,996,642–49,997,221 | 208.1 kb | Distal (>10kb) Multiome | 470 | |
| chr17:50,055,522–50,057,280 | 267.3 kb | Distal (>10kb) Multiome | 654 | |
| chr17:50,094,331–50,095,951 | 306.6 kb | Distal (>10kb) Multiome | 899 |
Genomic view of the KAT7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.