Enables methylated histone binding activity and transcription corepressor binding activity. Predicted to be involved in several processes, including negative regulation of gene expression, epigenetic; segment specification; and stem cell population maintenance. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MTF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:92,784,316–92,785,703 | 294.1 kb | Distal (>10kb) Multiome | 1089 | |
| chr1:92,831,415–92,832,738 | 247.2 kb | Distal (>10kb) Multiome | 1089 | |
| chr1:92,960,419–92,962,220 | 117.8 kb | Distal (>10kb) Multiome | 873 | |
| chr1:93,029,424–93,029,880 | 49.7 kb | Distal (>10kb) Multiome | 92 | |
| chr1:93,072,187–93,072,818 | 6.5 kb | Proximal (<10kb) | 16 | |
| chr1:93,078,561–93,080,172 | 62 bp | At TSS Multiome | 1219 | |
| chr1:93,179,586–93,181,175 | 101.2 kb | Distal (>10kb) Multiome | 1019 | |
| chr1:93,345,396–93,346,457 | 266.6 kb | Distal (>10kb) Multiome | 1003 |
Genomic view of the MTF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.