This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ESRRB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ESRRB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ESRRB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:76,136,532–76,137,578 | 239.1 kb | Distal (>10kb) Multiome HiCAR | 100 | |
| chr14:76,138,216–76,139,123 | 237.3 kb | Distal (>10kb) Multiome HiCAR | 309 | |
| chr14:76,151,503–76,152,617 | 224.2 kb | Distal (>10kb) Multiome | 754 | |
| chr14:76,313,693–76,314,977 | 61.8 kb | Distal (>10kb) Multiome | 88 | |
| chr14:76,375,931–76,376,323 | at TSS | At TSS | 167 | |
| chr14:76,403,008–76,403,704 | 27.2 kb | Distal (>10kb) Multiome | 16 | |
| chr14:76,563,507–76,564,002 | 187.6 kb | Distal (>10kb) Multiome | 13 |
Genomic view of the ESRRB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.