This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Transcription factors with Perturb-seq knockdown data for DEK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DEK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DEK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:17,986,741–17,988,454 | 276.8 kb | Distal (>10kb) Multiome | 815 | |
| chr6:18,022,711–18,023,230 | 241.6 kb | Distal (>10kb) Multiome | 195 | |
| chr6:18,122,030–18,123,058 | 141.9 kb | Distal (>10kb) Multiome | 824 | |
| chr6:18,141,867–18,142,341 | 122.5 kb | Distal (>10kb) Multiome | 113 | |
| chr6:18,152,627–18,153,245 | 111.7 kb | Distal (>10kb) Multiome | 199 | |
| chr6:18,154,608–18,156,434 | 109.3 kb | Distal (>10kb) Multiome | 937 | |
| chr6:18,185,739–18,186,332 | 78.4 kb | Distal (>10kb) Multiome | 189 | |
| chr6:18,260,678–18,261,010 | 3.3 kb | Proximal (<10kb) | 161 | |
| chr6:18,263,804–18,265,203 | 14 bp | At TSS Multiome | 869 | |
| chr6:18,265,932–18,266,202 | 1.7 kb | Proximal (<10kb) | 74 | |
| chr6:18,312,094–18,312,753 | 47.9 kb | Distal (>10kb) Multiome | 104 | |
| chr6:18,386,971–18,387,968 | 122.8 kb | Distal (>10kb) Multiome | 780 | |
| chr6:18,394,997–18,395,808 | 130.8 kb | Distal (>10kb) Multiome | 134 |
Genomic view of the DEK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.