chr16:56,675,665–56,676,180

chr16 : 56,675,665 – 56,676,180

515 bp 97 TFs 17 linked genes

This 515 bp open chromatin element is linked to 17 target genes and is bound by 97 transcription factors.

Linked Genes

17 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000290663		at TSS	At TSS	Proximity
MT1H		5.9 kb	Proximal	Proximity
MT1X		6.3 kb	Proximal	Proximity
ENSG00000259827		6.3 kb	Proximal	Proximity
MT1G		7.6 kb	Proximal	Proximity
MT1F		17.9 kb	Distal	Multiome
MT1A		37.2 kb	Distal	Multiome
MT1M		43.2 kb	Distal	Multiome
MT1E		50.1 kb	Distal	Multiome
NUP93		54.2 kb	Distal	Multiome
ENSG00000291105		58.5 kb	Distal	Multiome
MT2A		67.3 kb	Distal	Multiome
BBS2		155.8 kb	Distal	Multiome
OGFOD1		224.3 kb	Distal	Multiome
NUDT21		224.5 kb	Distal	Multiome
AMFR		250.3 kb	Distal	Multiome
HERPUD1		256.3 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

97 transcription factors

ChIP MDA-MB-453 ERP003503.AR.MDA-MB-453 153 bp overlap

ChIP prostate_cancer-associated-fibroblasts GSE90772.AR.prostate_cancer-associated-fibroblasts 441 bp overlap

ChIP prostate_fetal-fibroblast GSE90772.AR.prostate_fetal-fibroblast 215 bp overlap

ASH2L 1 dataset

ChIP WA01 ENCSR850KIP.ASH2L.WA01 515 bp overlap

BCL11B 1 dataset

ChIP thymus_CD34neg GSE84677.BCL11B.thymus_CD34neg 149 bp overlap

BCL6 3 datasets

ChIP CD4 GSE59933.BCL6.CD4 256 bp overlap

ChIP OCI-Ly1 GSE29282.BCL6.OCI-Ly1 249 bp overlap

ChIP RS4-11 GSE59541.BCL6.RS4-11 135 bp overlap

BCOR 4 datasets

ChIP WA01 GSE104690.BCOR.WA01 388 bp overlap

ChIP WA01_KDM2B_KO GSE104690.BCOR.WA01_KDM2B_KO 212 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 498 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 515 bp overlap

BHLHE40 2 datasets

ChIP GM12878 ENCFF521IZR 405 bp overlap

ChIP GM12878 ENCSR987MTA.BHLHE40.GM12878 230 bp overlap

ChIP HUES-64 GSE104059.BRD1.HUES-64 113 bp overlap

BRD4 8 datasets

ChIP CLL_patient2 GSE109411.BRD4.CLL_patient2 238 bp overlap

ChIP HUVEC-C GSE60171.BRD4.HUVEC-C 111 bp overlap

ChIP T-cell_DMSO GSE138084.BRD4.T-cell_DMSO 185 bp overlap

ChIP T-cell_iBET GSE138084.BRD4.T-cell_iBET 329 bp overlap

ChIP hESC GSE33281.BRD4.hESC 116 bp overlap

ChIP hESC GSE33281.BRD4.hESC 225 bp overlap

ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 424 bp overlap

ChIP retina_AB1-RB GSE86981.BRD4.retina_AB1-RB 420 bp overlap

ChIP ME-1 GSE46044.CBFB.ME-1 320 bp overlap

CDK9-HEXIM1 1 dataset

ChIP A-375 GSE68047.CDK9-HEXIM1.A-375 144 bp overlap

ChIP WA01 ENCSR000AQK.CHD1.WA01 65 bp overlap

ChIP colon_transverse ENCSR102CSD.CTCF.colon_transverse 290 bp overlap

CTCFL 1 dataset

ChIP K-562 GSE70764.CTCFL.K-562 211 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF031ISE 51 bp overlap

ChIP WA01 ENCSR000BSI.E2F6.WA01 155 bp overlap

ChIP NALM-6 GSE126300.EBF1.NALM-6 388 bp overlap

ChIP GM12878 ENCFF692SMY 391 bp overlap

EP300 2 datasets

ChIP 697 GSE138031.EP300.697 283 bp overlap

ChIP osteoblast ENCSR000AUD.EP300.osteoblast 515 bp overlap

ChIP CD34_NR29 GSE23730.ERG.CD34_NR29 309 bp overlap

ChIP K-562_DOX GSE23730.ERG.K-562_DOX 254 bp overlap

ChIP TSU-1621MT GSE60477.ERG.TSU-1621MT 225 bp overlap

ESR1 3 datasets

ChIP Ishikawa GSE99905.ESR1.Ishikawa 285 bp overlap

ChIP MCF-7_aldosterone GSE99626.ESR1.MCF-7_aldosterone 480 bp overlap

ChIP MCF-7_estradiol_45min_ChIP-and-reChIP GSE99626.ESR1.MCF-7_estradiol_45min_ChIP-and-reChIP 264 bp overlap

ETS1 6 datasets

ChIP CTV-1_DSG_SPI1-mut GSE128835.ETS1.CTV-1_DSG_SPI1-mut 212 bp overlap

ChIP HUVEC-C_12h GSE93030.ETS1.HUVEC-C_12h 164 bp overlap

ChIP HUVEC-C_VEGF_12H GSE41166.ETS1.HUVEC-C_VEGF_12H 164 bp overlap

ChIP HUVEC-C_VEGF_12h GSE109625.ETS1.HUVEC-C_VEGF_12h 164 bp overlap

ChIP cardiomyocyte_D0 GSE129986.ETS1.cardiomyocyte_D0 117 bp overlap

ChIP cardiomyocyte_D0 GSE129986.ETS1.cardiomyocyte_D0 296 bp overlap

EZH2 12 datasets

ChIP H1 ENCFF232NZA 438 bp overlap

ChIP H1 ENCFF232NZA 515 bp overlap

ChIP ProEs GSE59087.EZH2.ProEs 192 bp overlap

ChIP WA01 ENCSR000ASY.EZH2.WA01 515 bp overlap

ChIP astrocyte ENCSR000ARR.EZH2.astrocyte 515 bp overlap

ChIP endothelial_umbilical-vein ENCSR000ATA.EZH2.endothelial_umbilical-vein 515 bp overlap

ChIP hepatocyte ENCFF552DZB 343 bp overlap

ChIP hepatocyte ENCSR384LYW.EZH2.hepatocyte 515 bp overlap

ChIP neural progenitor cell ENCFF018MKA 428 bp overlap

ChIP neural progenitor cell ENCFF472NFV 337 bp overlap

ChIP neural progenitor cell ENCFF472NFV 263 bp overlap

ChIP neural_progenitor ENCSR069DPL.EZH2.neural_progenitor 515 bp overlap

EZH2_phosphoT487 2 datasets

ChIP hepatocyte ENCSR341VYI.EZH2_phosphoT487.hepatocyte 320 bp overlap

ChIP neural_progenitor ENCSR656MXA.EZH2_phosphoT487.neural_progenitor 515 bp overlap

FOXA1 1 dataset

ChIP breast-cancer_heregulin GSE101407.FOXA1.breast-cancer_heregulin 444 bp overlap

FOXO1 1 dataset

ChIP CD34 GSE80773.FOXO1.CD34 174 bp overlap

FOXP1 1 dataset

ChIP WTC11 ENCFF338WGC 354 bp overlap

GATA2 1 dataset

ChIP ME-1_CBFB-MYH11-KD GSE117138.GATA2.ME-1_CBFB-MYH11-KD 242 bp overlap

HDAC2 1 dataset

ChIP WA01 ENCSR000AVB.HDAC2.WA01 222 bp overlap

HNRNPK 2 datasets

ChIP Hep-G2 GSE120104.HNRNPK.Hep-G2 355 bp overlap

ChIP Hep-G2 ENCSR519QAA.HNRNPK.Hep-G2 225 bp overlap

IKZF1 1 dataset

ChIP pre-B-cell GSE107886.IKZF1.pre-B-cell 515 bp overlap

IKZF3 1 dataset

ChIP pre-B-cell GSE107886.IKZF3.pre-B-cell 515 bp overlap

ChIP T-cell GSE136853.IRF4.T-cell 515 bp overlap

JARID2 4 datasets

ChIP AMIPS6 GSE48516.JARID2.AMIPS6 213 bp overlap

ChIP MRC-5_IPS25_CTR GSE48515.JARID2.MRC-5_IPS25_CTR 173 bp overlap

ChIP MRC-5_IPS25_CTR GSE48515.JARID2.MRC-5_IPS25_CTR 235 bp overlap

ChIP MRC-5_IPS25_MEG3 GSE48515.JARID2.MRC-5_IPS25_MEG3 391 bp overlap

KDM1A 1 dataset

ChIP K-562 GSE117944.KDM1A.K-562 340 bp overlap

KDM4A 5 datasets

ChIP H1 ENCFF078LED 313 bp overlap

ChIP H1 ENCFF078LED 358 bp overlap

ChIP WA01 ENCSR000AVC.KDM4A.WA01 515 bp overlap

ChIP hiPSC_IIA11 GSE106870.KDM4A.hiPSC_IIA11 223 bp overlap

ChIP hiPSC_IID12 GSE106870.KDM4A.hiPSC_IID12 213 bp overlap

KDM6B 1 dataset

ChIP CUTLL1 GSE56694.KDM6B.CUTLL1 203 bp overlap

KMT2A 4 datasets

ChIP CCRF-CEM GSE83671.KMT2A.CCRF-CEM 268 bp overlap

ChIP KOPN-8 GSE83671.KMT2A.KOPN-8 190 bp overlap

ChIP RCH-ACV GSE83671.KMT2A.RCH-ACV 515 bp overlap

ChIP RS4-11_DMSO-D3-180402 GSE127507.KMT2A.RS4-11_DMSO-D3-180402 383 bp overlap

LARP7 1 dataset

ChIP GM12878 ENCFF513CEX 438 bp overlap

ChIP THP-1_macrophage_PMA GSE96800.MAF1.THP-1_macrophage_PMA 163 bp overlap

ChIP WTC11 ENCFF223QFY 376 bp overlap

ChIP WTC11 ENCFF223QFY 515 bp overlap

Motif DE_12h DE_12h-MAZ_MA1522.2 8 bp overlap

Motif ES_0h ES_0h-MAZ_MA1522.2 8 bp overlap

MECOM 1 dataset

ChIP SKH1_CEBPA-ER GSE102697.MECOM.SKH1_CEBPA-ER 177 bp overlap

ChIP melanocyte_CTR GSE50681.MITF.melanocyte_CTR 205 bp overlap

ChIP pre-B-cell GSE107886.MTA2.pre-B-cell 515 bp overlap

ChIP PF-382 GSE94000.MYB.PF-382 231 bp overlap

NANOG 3 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 313 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 220 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 328 bp overlap

NFKB1 2 datasets

ChIP HEK293T GSE129618.NFKB1.HEK293T 239 bp overlap

ChIP HEK293T_2KR GSE129618.NFKB1.HEK293T_2KR 373 bp overlap

NR3C1 3 datasets

ChIP A-549 ENCSR000BJR.NR3C1.A-549 104 bp overlap

ChIP ALL_DEX GSE109946.NR3C1.ALL_DEX 239 bp overlap

ChIP SUP-B15_DEX GSE107584.NR3C1.SUP-B15_DEX 345 bp overlap

OGG1 3 datasets

ChIP HEK293 GSE89017.OGG1.HEK293 425 bp overlap

ChIP HEK293_15min GSE89017.OGG1.HEK293_15min 436 bp overlap

ChIP HEK293_60_min GSE89017.OGG1.HEK293_60_min 352 bp overlap

PATZ1 2 datasets

Motif DE_12h DE_12h-PATZ1_MA1961.2 11 bp overlap

Motif ES_0h ES_0h-PATZ1_MA1961.2 11 bp overlap

PAX5 2 datasets

ChIP NALM-6 GSE126300.PAX5.NALM-6 515 bp overlap

ChIP NALM-6 GSE115764.PAX5.NALM-6 312 bp overlap

ChIP OVSAHO GSE79893.PAX8.OVSAHO 60 bp overlap

ChIP RCH-ACV GSE85988.PBX1.RCH-ACV 515 bp overlap

PCGF1 1 dataset

ChIP WA01 GSE104690.PCGF1.WA01 515 bp overlap

PCGF2 1 dataset

ChIP fibroblast_MET GSE55605.PCGF2.fibroblast_MET 103 bp overlap

ChIP myometrium_NP1 GSE137550.PGR.myometrium_NP1 248 bp overlap

POLR2A 4 datasets

ChIP GM23338 ENCFF450WCS 177 bp overlap

ChIP GM23338 ENCFF450WCS 184 bp overlap

ChIP transverse colon ENCFF193UMS 206 bp overlap

ChIP transverse colon ENCFF607LKE 215 bp overlap

POU2AF1 1 dataset

ChIP pre-B-cell GSE107886.POU2AF1.pre-B-cell 283 bp overlap

POU5F1 4 datasets

ChIP BG03 GSE21614.POU5F1.BG03 412 bp overlap

ChIP DE_D1 DED1-OCT4_Batch_II 360 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 467 bp overlap

ChIP WA01_3IL ERP004238.POU5F1.WA01_3IL 286 bp overlap

RAD21 1 dataset

ChIP hiPSC_CVI GSE106870.RAD21.hiPSC_CVI 127 bp overlap

ChIP TSU-1621MT GSE60477.RARA.TSU-1621MT 220 bp overlap

RBBP5 1 dataset

ChIP WA01 ENCSR000AQC.RBBP5.WA01 382 bp overlap

REST 2 datasets

ChIP CD4 GSE49570.REST.CD4 152 bp overlap

ChIP K-562 ENCSR000BMW.REST.K-562 140 bp overlap

RNF2 3 datasets

ChIP WA01 ENCSR784VUY.RNF2.WA01 349 bp overlap

ChIP WA09 GSE105028.RNF2.WA09 458 bp overlap

ChIP WA09_heat-shock GSE105028.RNF2.WA09_heat-shock 515 bp overlap

RORC 2 datasets

ChIP HCC70 GSE126380.RORC.HCC70 431 bp overlap

ChIP HCC70_XY018 GSE126380.RORC.HCC70_XY018 484 bp overlap

RUNX1 6 datasets

ChIP 697 GSE138031.RUNX1.697 343 bp overlap

ChIP AML GSE111821.RUNX1.AML 300 bp overlap

ChIP AML_Blast GSE60130.RUNX1.AML_Blast 257 bp overlap

ChIP CD34 GSE64862.RUNX1.CD34 257 bp overlap

ChIP NALM-6 GSE126300.RUNX1.NALM-6 515 bp overlap

ChIP epididymis_HEE GSE109061.RUNX1.epididymis_HEE 182 bp overlap

ChIP TSU-1621MT GSE60477.RXR.TSU-1621MT 217 bp overlap

ChIP WA01 GSE104690.RYBP.WA01 493 bp overlap

SALL3 1 dataset

ChIP hiPSC GSE104863.SALL3.hiPSC 515 bp overlap

SAP30 1 dataset

ChIP WA01 ENCSR000ATR.SAP30.WA01 177 bp overlap

SIN3A 2 datasets

ChIP hiPSC_IB12 GSE106870.SIN3A.hiPSC_IB12 414 bp overlap

ChIP hiPSC_IID12 GSE106870.SIN3A.hiPSC_IID12 207 bp overlap

SMARCA4 1 dataset

ChIP 22Rv1_PTEN-KO GSE115615.SMARCA4.22Rv1_PTEN-KO 206 bp overlap

SOX11 1 dataset

ChIP GRANT-A519 GSE52146.SOX11.GRANT-A519 90 bp overlap

Motif ES_0h ES_0h-SP1_MA0079.5 9 bp overlap

Motif DE_12h DE_12h-SP5_MA1965.2 6 bp overlap

Motif ES_0h ES_0h-SP5_MA1965.2 6 bp overlap

SREBP2 3 datasets

ChIP HCC70 GSE126380.SREBP2.HCC70 458 bp overlap

ChIP HCC70_XY018 GSE126380.SREBP2.HCC70_XY018 424 bp overlap

ChIP monocyte_TNF GSE129202.SREBP2.monocyte_TNF 389 bp overlap

STAT1 1 dataset

ChIP CD14_LPS GSE43036.STAT1.CD14_LPS 197 bp overlap

STAT3 1 dataset

ChIP WA01 ERP004237.STAT3.WA01 318 bp overlap

STAT5B 4 datasets

ChIP CD8_H9 GSE64713.STAT5B.CD8_H9 305 bp overlap

ChIP CD8_H9RET GSE64713.STAT5B.CD8_H9RET 259 bp overlap

ChIP CD8_H9RETR GSE64713.STAT5B.CD8_H9RETR 213 bp overlap

ChIP CD8_IL2 GSE64713.STAT5B.CD8_IL2 296 bp overlap

SUZ12 4 datasets

ChIP CRL-7250_shSS18 GSE108025.SUZ12.CRL-7250_shSS18 515 bp overlap

ChIP CRL-7250_shSS18-SSX GSE108025.SUZ12.CRL-7250_shSS18-SSX 300 bp overlap

ChIP hiPSC GSE124903.SUZ12.hiPSC 515 bp overlap

ChIP hiPSC_WT GSE124903.SUZ12.hiPSC_WT 515 bp overlap

ChIP WA01 ENCSR000BHO.TAF1.WA01 154 bp overlap

ChIP hESC_2h GSE122298.TBP.hESC_2h 515 bp overlap

ChIP hESC_8h GSE122298.TBP.hESC_8h 169 bp overlap

ChIP RCH-ACV GSE85988.TCF3.RCH-ACV 515 bp overlap

ChIP LS180_125 GSE31939.TCF4.LS180_125 102 bp overlap

TEAD1 1 dataset

ChIP H69 GSE62274.TEAD1.H69 174 bp overlap

TFAP2C 2 datasets

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 390 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 386 bp overlap

TFIIIC 1 dataset

ChIP HEK293 GSE119418.TFIIIC.HEK293 374 bp overlap

ChIP keratinocyte GSE33571.TP63.keratinocyte 134 bp overlap

TRIM25 1 dataset

ChIP BT-549 GSE79588.TRIM25.BT-549 291 bp overlap

VEZF1 1 dataset

ChIP K562 ENCFF053XDV 515 bp overlap

ChIP SMMC-7721 GSE126982.WDR5.SMMC-7721 396 bp overlap

Motif DE_12h DE_12h-Wt1_MA1627.2 10 bp overlap

Motif ES_0h ES_0h-Wt1_MA1627.2 10 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 173 bp overlap

ChIP liver ENCSR994YLZ.YY1.liver 119 bp overlap

ZBTB7A 2 datasets

ChIP K-562 ENCSR000BME.ZBTB7A.K-562 93 bp overlap

ChIP VCaP_DHT GSE123089.ZBTB7A.VCaP_DHT 297 bp overlap

ChIP GM12878 ENCSR000BND.ZEB1.GM12878 125 bp overlap

ZNF148 2 datasets

Motif DE_12h DE_12h-ZNF148_MA1653.2 10 bp overlap

Motif ES_0h ES_0h-ZNF148_MA1653.2 10 bp overlap

ZNF281 3 datasets

Motif DE_12h DE_12h-ZNF281_MA1630.3 10 bp overlap

Motif ES_0h ES_0h-ZNF281_MA1630.3 10 bp overlap

ChIP K-562 GSE121133.ZNF281.K-562 142 bp overlap