This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for LARP7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LARP7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LARP7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:112,361,159–112,361,926 | 275.5 kb | Distal (>10kb) Multiome | 209 | |
| chr4:112,378,884–112,379,732 | 257.7 kb | Distal (>10kb) Multiome | 230 | |
| chr4:112,509,466–112,511,736 | 126.1 kb | Distal (>10kb) Multiome | 299 | |
| chr4:112,514,488–112,516,977 | 120.5 kb | Distal (>10kb) Multiome | 586 | |
| chr4:112,522,782–112,524,704 | 113.0 kb | Distal (>10kb) Multiome | 638 | |
| chr4:112,633,508–112,633,715 | 3.4 kb | Proximal (<10kb) | 65 | |
| chr4:112,636,483–112,637,927 | 101 bp | At TSS Multiome | 891 | |
| chr4:112,641,078–112,641,590 | 4.0 kb | Proximal (<10kb) | 5 | |
| chr4:112,641,720–112,642,218 | 4.6 kb | Proximal (<10kb) | 15 | |
| chr4:112,642,445–112,646,414 | 8.7 kb | Proximal (<10kb) Multiome | 296 | |
| chr4:112,647,946–112,649,404 | 11.8 kb | Distal (>10kb) Multiome | 235 | |
| chr4:112,650,387–112,650,650 | 4.8 kb | Proximal (<10kb) | 24 | |
| chr4:112,651,007–112,651,505 | 5.4 kb | Proximal (<10kb) | 17 | |
| chr4:112,651,652–112,651,795 | 6.0 kb | Proximal (<10kb) | 12 | |
| chr4:112,651,910–112,652,787 | 6.3 kb | Proximal (<10kb) | 160 | |
| chr4:112,654,381–112,654,747 | 8.8 kb | Proximal (<10kb) | 14 | |
| chr4:112,655,012–112,655,964 | 9.4 kb | Proximal (<10kb) | 48 | |
| chr4:112,706,097–112,706,856 | 69.4 kb | Distal (>10kb) Multiome | 313 | |
| chr4:112,746,884–112,747,846 | 110.1 kb | Distal (>10kb) Multiome HiCAR | 275 | |
| chr4:112,751,041–112,752,361 | 114.6 kb | Distal (>10kb) Multiome HiCAR | 200 | |
| chr4:112,759,125–112,759,682 | 122.4 kb | Distal (>10kb) Multiome HiCAR | 195 | |
| chr4:112,817,726–112,818,715 | 181.1 kb | Distal (>10kb) Multiome | 463 | |
| chr4:112,854,045–112,854,900 | 217.4 kb | Distal (>10kb) Multiome | 101 | |
| chr4:112,860,814–112,861,553 | 224.1 kb | Distal (>10kb) Multiome | 167 |
Genomic view of the LARP7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.