This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity. [provided by RefSeq, Sep 2017]
Transcription factors with Perturb-seq knockdown data for MT1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MT1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MT1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:56,356,409–56,357,020 | 282.1 kb | Distal (>10kb) Multiome | 736 | |
| chr16:56,424,368–56,425,945 | 213.2 kb | Distal (>10kb) Multiome | 582 | |
| chr16:56,450,882–56,452,062 | 187.2 kb | Distal (>10kb) Multiome | 828 | |
| chr16:56,519,537–56,520,432 | 118.7 kb | Distal (>10kb) Multiome | 798 | |
| chr16:56,547,229–56,547,931 | 91.1 kb | Distal (>10kb) Multiome | 198 | |
| chr16:56,608,175–56,608,748 | 30.2 kb | Distal (>10kb) Multiome | 861 | |
| chr16:56,625,188–56,625,919 | 13.0 kb | Distal (>10kb) Multiome | 474 | |
| chr16:56,632,101–56,632,676 | 6.2 kb | Proximal (<10kb) Multiome | 180 | |
| chr16:56,638,359–56,638,738 | at TSS | At TSS | 252 | |
| chr16:56,643,360–56,643,746 | 4.7 kb | Proximal (<10kb) | 373 | |
| chr16:56,657,372–56,658,310 | 19.1 kb | Distal (>10kb) Multiome | 494 | |
| chr16:56,668,023–56,668,619 | 29.5 kb | Distal (>10kb) Multiome | 379 | |
| chr16:56,675,665–56,676,180 | 37.2 kb | Distal (>10kb) Multiome | 97 | |
| chr16:56,681,954–56,682,716 | 43.7 kb | Distal (>10kb) Multiome | 699 | |
| chr16:56,729,523–56,730,762 | 91.4 kb | Distal (>10kb) Multiome | 819 | |
| chr16:56,931,455–56,933,141 | 293.4 kb | Distal (>10kb) Multiome | 1047 |
Genomic view of the MT1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.