This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FOXO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:40,210,750–40,211,538 | 455.5 kb | Distal (>10kb) Multiome HiCAR | 30 | |
| chr13:40,232,425–40,233,123 | 433.8 kb | Distal (>10kb) Multiome HiCAR | 47 | |
| chr13:40,355,207–40,355,904 | 311.2 kb | Distal (>10kb) Multiome HiCAR | 73 | |
| chr13:40,651,850–40,652,501 | 14.5 kb | Distal (>10kb) Multiome | 187 | |
| chr13:40,663,960–40,667,930 | 83 bp | At TSS Multiome | 878 | |
| chr13:40,668,233–40,668,565 | 1.6 kb | Proximal (<10kb) | 167 | |
| chr13:40,671,261–40,671,839 | 4.6 kb | Proximal (<10kb) | 12 | |
| chr13:40,672,531–40,672,680 | 5.9 kb | Proximal (<10kb) | 271 | |
| chr13:40,680,324–40,681,411 | 14.2 kb | Distal (>10kb) Multiome | 281 | |
| chr13:40,770,737–40,771,525 | 104.6 kb | Distal (>10kb) Multiome | 1000 | |
| chr13:40,789,168–40,790,225 | 122.9 kb | Distal (>10kb) Multiome | 837 | |
| chr13:40,921,270–40,922,017 | 255.0 kb | Distal (>10kb) Multiome | 675 |
Genomic view of the FOXO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.