The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020]
Transcription factors with Perturb-seq knockdown data for STAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:190,860,849–190,861,826 | 152.8 kb | Distal (>10kb) Multiome | 191 | |
| chr2:190,869,557–190,870,549 | 144.2 kb | Distal (>10kb) Multiome | 91 | |
| chr2:190,880,124–190,882,292 | 132.2 kb | Distal (>10kb) Multiome | 1086 | |
| chr2:191,013,523–191,014,882 | 53 bp | At TSS Multiome | 1090 | |
| chr2:191,020,168–191,020,996 | 6.3 kb | Proximal (<10kb) Multiome | 1169 | |
| chr2:191,049,645–191,052,413 | 36.0 kb | Distal (>10kb) Multiome | 448 | |
| chr2:191,150,245–191,151,620 | 136.8 kb | Distal (>10kb) Multiome | 430 | |
| chr2:191,155,578–191,156,319 | 141.7 kb | Distal (>10kb) Multiome | 129 | |
| chr2:191,166,129–191,168,453 | 152.6 kb | Distal (>10kb) Multiome | 369 | |
| chr2:191,244,968–191,246,655 | 232.0 kb | Distal (>10kb) Multiome | 961 | |
| chr2:191,250,888–191,251,582 | 237.1 kb | Distal (>10kb) Multiome | 95 | |
| chr2:191,301,718–191,302,748 | 288.0 kb | Distal (>10kb) Multiome | 115 |
Genomic view of the STAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.