The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NUDT21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUDT21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUDT21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:56,190,607–56,192,076 | 260.0 kb | Distal (>10kb) Multiome | 450 | |
| chr16:56,194,047–56,194,919 | 256.8 kb | Distal (>10kb) Multiome | 346 | |
| chr16:56,281,237–56,281,831 | 169.7 kb | Distal (>10kb) Multiome | 230 | |
| chr16:56,289,711–56,290,418 | 161.3 kb | Distal (>10kb) Multiome | 224 | |
| chr16:56,318,032–56,318,622 | 132.9 kb | Distal (>10kb) Multiome | 401 | |
| chr16:56,356,409–56,357,020 | 94.7 kb | Distal (>10kb) Multiome | 736 | |
| chr16:56,424,368–56,425,945 | 25.8 kb | Distal (>10kb) Multiome | 582 | |
| chr16:56,450,882–56,452,062 | 115 bp | At TSS Multiome | 828 | |
| chr16:56,519,537–56,520,432 | 68.7 kb | Distal (>10kb) Multiome | 798 | |
| chr16:56,547,229–56,547,931 | 96.3 kb | Distal (>10kb) Multiome | 198 | |
| chr16:56,608,175–56,608,748 | 157.2 kb | Distal (>10kb) Multiome | 861 | |
| chr16:56,625,188–56,625,919 | 174.3 kb | Distal (>10kb) Multiome | 474 | |
| chr16:56,632,101–56,632,676 | 181.1 kb | Distal (>10kb) Multiome | 180 | |
| chr16:56,657,372–56,658,310 | 206.4 kb | Distal (>10kb) Multiome | 494 | |
| chr16:56,668,023–56,668,619 | 216.8 kb | Distal (>10kb) Multiome | 379 | |
| chr16:56,675,665–56,676,180 | 224.5 kb | Distal (>10kb) Multiome | 97 | |
| chr16:56,681,954–56,682,716 | 231.0 kb | Distal (>10kb) Multiome | 699 | |
| chr16:56,729,523–56,730,762 | 278.8 kb | Distal (>10kb) Multiome | 819 |
Genomic view of the NUDT21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.