MTA2

metastasis associated 1 family member 2 | MTA1-L1, MTA1L1

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

Member of: DE-6

Biological processes 40 terms

DNA-binding transcription factor binding (GO:0140297)NuRD complex (GO:0016581)NuRD complex (GO:0016581)NuRD complex (GO:0016581)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)chromatin (GO:0000785)chromatin binding (GO:0003682)chromatin organization (GO:0006325)chromatin remodeling (GO:0006338)chromatin remodeling (GO:0006338)chromatin remodeling (GO:0006338)chromosome, telomeric region (GO:0000781)histone deacetylase activity (GO:0004407)histone deacetylase binding (GO:0042826)histone deacetylase binding (GO:0042826)histone deacetylase complex (GO:0000118)histone deacetylase complex (GO:0000118)membrane (GO:0016020)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleosomal DNA binding (GO:0031492)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)protein binding (GO:0005515)protein-containing complex (GO:0032991)regulation of DNA-templated transcription (GO:0006355)regulation of cell fate specification (GO:0042659)regulation of fibroblast migration (GO:0010762)regulation of stem cell differentiation (GO:2000736)sequence-specific DNA binding (GO:0043565)transcription coactivator activity (GO:0003713)transcription coregulator activity (GO:0003712)transcription corepressor activity (GO:0003714)transcription regulator complex (GO:0005667)

Expression (TPM)

TFs regulating MTA2 0 TFs

Transcription factors with Perturb-seq knockdown data for MTA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MTA2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr11:62,337,140–62,338,142	264.4 kb	Distal (>10kb) Multiome	611
chr11:62,382,190–62,383,008	219.2 kb	Distal (>10kb) Multiome	36
chr11:62,460,403–62,461,004	141.1 kb	Distal (>10kb) Multiome	20
chr11:62,508,289–62,508,878	93.3 kb	Distal (>10kb) Multiome	499
chr11:62,542,658–62,543,488	58.9 kb	Distal (>10kb) Multiome	537
chr11:62,545,051–62,547,562	54.8 kb	Distal (>10kb) Multiome	889
chr11:62,553,213–62,553,741	48.4 kb	Distal (>10kb) Multiome	489
chr11:62,555,905–62,556,742	45.6 kb	Distal (>10kb) Multiome	545
chr11:62,560,588–62,561,104	41.2 kb	Distal (>10kb) Multiome	541
chr11:62,561,760–62,562,358	39.8 kb	Distal (>10kb) Multiome	43
chr11:62,573,347–62,574,645	27.8 kb	Distal (>10kb) Multiome	845
chr11:62,591,246–62,592,462	10.1 kb	Distal (>10kb) Multiome	976
chr11:62,593,640–62,593,821	8.0 kb	Proximal (<10kb)	261
chr11:62,599,145–62,599,532	2.3 kb	Proximal (<10kb)	580
chr11:62,600,988–62,603,291	74 bp	At TSS Multiome	872
chr11:62,606,867–62,607,281	5.0 kb	Proximal (<10kb)	37
chr11:62,611,665–62,613,544	11.0 kb	Distal (>10kb) Multiome	737
chr11:62,621,550–62,622,445	20.2 kb	Distal (>10kb) Multiome	964
chr11:62,646,025–62,647,031	44.8 kb	Distal (>10kb) Multiome	815
chr11:62,652,836–62,653,744	51.5 kb	Distal (>10kb) Multiome	921
chr11:62,664,567–62,666,291	63.4 kb	Distal (>10kb) Multiome	1020
chr11:62,671,328–62,672,522	69.9 kb	Distal (>10kb) Multiome	882
chr11:62,705,543–62,707,930	104.5 kb	Distal (>10kb) Multiome	760
chr11:62,708,691–62,710,293	107.8 kb	Distal (>10kb) Multiome	531
chr11:62,726,557–62,728,947	125.7 kb	Distal (>10kb) Multiome	1088
chr11:62,753,347–62,754,665	152.3 kb	Distal (>10kb) Multiome	696
chr11:62,761,085–62,762,045	159.6 kb	Distal (>10kb) Multiome	649
chr11:62,770,753–62,772,068	169.6 kb	Distal (>10kb) Multiome	885
chr11:62,786,365–62,787,860	184.7 kb	Distal (>10kb) Multiome	1073
chr11:62,791,569–62,792,385	190.2 kb	Distal (>10kb) Multiome	805
chr11:62,804,451–62,807,080	203.7 kb	Distal (>10kb) Multiome	994
chr11:62,831,037–62,832,904	230.1 kb	Distal (>10kb) Multiome	870
chr11:62,839,042–62,842,743	239.5 kb	Distal (>10kb) Multiome	1403
chr11:62,851,028–62,851,955	249.6 kb	Distal (>10kb) Multiome	421
chr11:62,855,209–62,856,560	254.1 kb	Distal (>10kb) Multiome	1071
chr11:62,862,252–62,862,948	260.8 kb	Distal (>10kb) Multiome	360
chr11:62,880,343–62,881,977	279.0 kb	Distal (>10kb) Multiome	1080

Genome Browser

Genomic view of the MTA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.