OGFOD1
2-oxoglutarate and iron dependent oxygenase domain containing 1 | FLJ10826, KIAA1612, TPA1

Enables peptidyl-proline 3-dioxygenase activity. Involved in several processes, including peptidyl-proline hydroxylation; regulation of translational termination; and stress granule assembly. Located in cytoplasmic stress granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 24 terms
2-oxoglutarate-dependent dioxygenase activity (GO:0016706)L-ascorbic acid binding (GO:0031418)cell population proliferation (GO:0008283)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic stress granule (GO:0010494)cytosol (GO:0005829)iron ion binding (GO:0005506)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705)peptidyl-proline 3-dioxygenase activity (GO:0031544)peptidyl-proline 3-dioxygenase activity (GO:0031544)peptidyl-proline dioxygenase activity (GO:0031543)peptidyl-proline dioxygenase activity (GO:0031543)peptidyl-proline dioxygenase activity (GO:0031543)peptidyl-proline hydroxylation (GO:0019511)peptidyl-proline hydroxylation (GO:0019511)protein binding (GO:0005515)protein hydroxylation (GO:0018126)regulation of translational termination (GO:0006449)regulation of translational termination (GO:0006449)stress granule assembly (GO:0034063)
Expression (TPM)
OGFOD1 — as a Regulated Gene

TFs regulating OGFOD1 0 TFs

Transcription factors with Perturb-seq knockdown data for OGFOD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OGFOD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to OGFOD1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OGFOD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:56,190,607–56,192,076 260.2 kb Distal (>10kb) Multiome 450
chr16:56,194,047–56,194,919 257.0 kb Distal (>10kb) Multiome 346
chr16:56,281,237–56,281,831 169.9 kb Distal (>10kb) Multiome 230
chr16:56,289,711–56,290,418 161.5 kb Distal (>10kb) Multiome 224
chr16:56,318,032–56,318,622 133.1 kb Distal (>10kb) Multiome 401
chr16:56,356,409–56,357,020 94.9 kb Distal (>10kb) Multiome 736
chr16:56,424,368–56,425,945 26.1 kb Distal (>10kb) Multiome 582
chr16:56,450,882–56,452,062 114 bp At TSS Multiome 828
chr16:56,519,537–56,520,432 68.4 kb Distal (>10kb) Multiome 798
chr16:56,547,229–56,547,931 96.1 kb Distal (>10kb) Multiome 198
chr16:56,608,175–56,608,748 157.0 kb Distal (>10kb) Multiome 861
chr16:56,625,188–56,625,919 174.1 kb Distal (>10kb) Multiome 474
chr16:56,632,101–56,632,676 180.9 kb Distal (>10kb) Multiome 180
chr16:56,657,372–56,658,310 206.2 kb Distal (>10kb) Multiome 494
chr16:56,668,023–56,668,619 216.6 kb Distal (>10kb) Multiome 379
chr16:56,675,665–56,676,180 224.3 kb Distal (>10kb) Multiome 97
chr16:56,681,954–56,682,716 230.8 kb Distal (>10kb) Multiome 699
chr16:56,729,523–56,730,762 278.5 kb Distal (>10kb) Multiome 819

Genome Browser

Genomic view of the OGFOD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:56,180,607 – 56,740,762
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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