Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MT1H. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MT1H upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MT1H, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:56,424,368–56,425,945 | 244.3 kb | Distal (>10kb) Multiome | 582 | |
| chr16:56,450,882–56,452,062 | 218.4 kb | Distal (>10kb) Multiome | 828 | |
| chr16:56,519,537–56,520,432 | 149.9 kb | Distal (>10kb) Multiome | 798 | |
| chr16:56,547,229–56,547,931 | 122.2 kb | Distal (>10kb) Multiome | 198 | |
| chr16:56,608,175–56,608,748 | 61.3 kb | Distal (>10kb) Multiome | 861 | |
| chr16:56,625,188–56,625,919 | 44.1 kb | Distal (>10kb) Multiome | 474 | |
| chr16:56,632,101–56,632,676 | 37.4 kb | Distal (>10kb) Multiome | 180 | |
| chr16:56,657,372–56,658,310 | 12.0 kb | Distal (>10kb) Multiome | 494 | |
| chr16:56,668,023–56,668,619 | 1.7 kb | Proximal (<10kb) Multiome | 379 | |
| chr16:56,669,524–56,669,798 | 14 bp | At TSS | 97 | |
| chr16:56,675,665–56,676,180 | 6.1 kb | Proximal (<10kb) Multiome | 97 | |
| chr16:56,681,954–56,682,716 | 12.5 kb | Distal (>10kb) Multiome | 699 | |
| chr16:56,729,523–56,730,762 | 60.3 kb | Distal (>10kb) Multiome | 819 | |
| chr16:56,931,455–56,933,141 | 262.3 kb | Distal (>10kb) Multiome | 1047 |
Genomic view of the MT1H locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.