This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]
Transcription factors with Perturb-seq knockdown data for OGG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OGG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OGG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:9,499,948–9,500,976 | 249.3 kb | Distal (>10kb) Multiome | 320 | |
| chr3:9,552,048–9,552,879 | 197.5 kb | Distal (>10kb) Multiome | 372 | |
| chr3:9,553,391–9,554,161 | 196.1 kb | Distal (>10kb) Multiome | 128 | |
| chr3:9,649,068–9,649,746 | 100.6 kb | Distal (>10kb) Multiome | 793 | |
| chr3:9,703,572–9,705,701 | 44.8 kb | Distal (>10kb) Multiome | 664 | |
| chr3:9,727,013–9,727,518 | 22.7 kb | Distal (>10kb) Multiome | 264 | |
| chr3:9,730,724–9,732,470 | 18.6 kb | Distal (>10kb) Multiome | 934 | |
| chr3:9,749,252–9,750,525 | 8 bp | At TSS Multiome | 873 | |
| chr3:9,769,503–9,770,124 | 20.0 kb | Distal (>10kb) Multiome | 504 | |
| chr3:9,792,176–9,793,536 | 42.9 kb | Distal (>10kb) Multiome | 915 | |
| chr3:9,809,609–9,810,744 | 60.2 kb | Distal (>10kb) Multiome | 437 | |
| chr3:9,843,116–9,844,397 | 94.0 kb | Distal (>10kb) Multiome | 787 | |
| chr3:9,862,465–9,863,231 | 112.9 kb | Distal (>10kb) Multiome | 581 | |
| chr3:9,890,247–9,891,058 | 140.7 kb | Distal (>10kb) Multiome | 969 | |
| chr3:9,902,504–9,903,128 | 152.8 kb | Distal (>10kb) Multiome | 396 | |
| chr3:9,914,983–9,916,160 | 165.3 kb | Distal (>10kb) Multiome | 668 | |
| chr3:9,916,644–9,917,412 | 167.1 kb | Distal (>10kb) Multiome | 519 | |
| chr3:9,932,470–9,934,327 | 182.8 kb | Distal (>10kb) Multiome | 1035 | |
| chr3:9,946,152–9,947,739 | 196.7 kb | Distal (>10kb) Multiome | 898 | |
| chr3:9,951,898–9,952,503 | 202.3 kb | Distal (>10kb) Multiome | 484 | |
| chr3:9,986,547–9,987,409 | 237.0 kb | Distal (>10kb) Multiome | 907 | |
| chr3:10,008,678–10,009,458 | 259.2 kb | Distal (>10kb) Multiome | 240 | |
| chr3:10,010,580–10,011,700 | 261.3 kb | Distal (>10kb) Multiome | 540 | |
| chr3:10,025,904–10,026,762 | 276.4 kb | Distal (>10kb) Multiome | 871 |
Genomic view of the OGG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.