chr14:73,235,444–73,236,071

chr14 : 73,235,444 – 73,236,071

627 bp 85 TFs 6 linked genes

This 627 bp open chromatin element is linked to 6 target genes and is bound by 85 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
PAPLN		1.4 kb	Proximal	Proximity
PAPLN-AS1		9.9 kb	Proximal	Proximity
PSEN1		99.3 kb	Distal	Multiome
RBM25		177.2 kb	Distal	Multiome
ZFYVE1		208.6 kb	Distal	Multiome
NUMB		222.8 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

85 transcription factors

ARID4B 1 dataset

ChIP WTC11 ENCFF441HDK 431 bp overlap

ASH2L 2 datasets

ChIP H1 ENCFF399KAM 356 bp overlap

ChIP WA01 ENCSR850KIP.ASH2L.WA01 627 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 221 bp overlap

BACH1 1 dataset

ChIP WA01 ENCSR000EBQ.BACH1.WA01 400 bp overlap

BCL11A 1 dataset

ChIP WA01 ENCSR000BIP.BCL11A.WA01 132 bp overlap

BCOR 4 datasets

ChIP WA01 GSE104690.BCOR.WA01 540 bp overlap

ChIP WA01_KDM2B_KO GSE104690.BCOR.WA01_KDM2B_KO 187 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 317 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 591 bp overlap

BORCS8-MEF2B,MEF2B 1 dataset

ChIP GM12878 ENCFF427QAI 559 bp overlap

ChIP HUES-64 GSE104059.BRD1.HUES-64 367 bp overlap

ChIP K-562_iBET-IFNG GSE138084.BRD2.K-562_iBET-IFNG 266 bp overlap

BRD4 3 datasets

ChIP NCI-H1963_shASXL3 GSE145028.BRD4.NCI-H1963_shASXL3 367 bp overlap

ChIP NCI-H1963_shNONT GSE145028.BRD4.NCI-H1963_shNONT 492 bp overlap

ChIP retina_AB1-RB GSE86981.BRD4.retina_AB1-RB 216 bp overlap

CBFA2T3 2 datasets

ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 265 bp overlap

ChIP K562 ENCFF673OEZ 411 bp overlap

CEBPB 1 dataset

ChIP MV4-11 GSE88746.CEBPB.MV4-11 204 bp overlap

CHD7 3 datasets

ChIP H1 ENCFF126NLU 418 bp overlap

ChIP H1 ENCFF126NLU 219 bp overlap

ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 593 bp overlap

CREB1 1 dataset

ChIP GM23338 ENCSR214ZAV.CREB1.GM23338 146 bp overlap

CTBP2 2 datasets

ChIP H1 ENCFF329MAX 544 bp overlap

ChIP WA01 ENCSR000EUO.CTBP2.WA01 503 bp overlap

CTCF 3 datasets

ChIP choroid plexus epithelial cell ENCFF407YNR 277 bp overlap

ChIP choroid-plexus_epithelial ENCSR000DTL.CTCF.choroid-plexus_epithelial 176 bp overlap

ChIP endodermal cell ENCFF471YCZ 419 bp overlap

ChIP HeLa-S3 ENCSR219MKK.DEK.HeLa-S3 112 bp overlap

ChIP HeLa-S3 ENCSR219MKK.DEK.HeLa-S3 166 bp overlap

EBF1 5 datasets

ChIP GM12878 ENCFF167CZS 321 bp overlap

ChIP GM12878 ENCFF813OXE 265 bp overlap

ChIP GM12878 ENCSR000DZQ.EBF1.GM12878 141 bp overlap

ChIP MUTUL GSE75503.EBF1.MUTUL 379 bp overlap

ChIP NALM-6 GSE126300.EBF1.NALM-6 314 bp overlap

ChIP PDAC_KOKLF5 GSE64557.ELF3.PDAC_KOKLF5 304 bp overlap

EP300 2 datasets

ChIP WA01 ENCSR000BKK.EP300.WA01 217 bp overlap

ChIP osteoblast ENCSR000AUD.EP300.osteoblast 627 bp overlap

ChIP VCaP GSE49091.ERG.VCaP 125 bp overlap

ESR1 2 datasets

ChIP MCF-7_PaPE-1 GSE93510.ESR1.MCF-7_PaPE-1 126 bp overlap

ChIP T-47D_Y537S GSE148277.ESR1.T-47D_Y537S 326 bp overlap

EZH2 12 datasets

ChIP A-1847_CARM1-KO GSE95643.EZH2.A-1847_CARM1-KO 453 bp overlap

ChIP GM23338 ENCSR045YHA.EZH2.GM23338 610 bp overlap

ChIP SU-DHL-6 GSE134136.EZH2.SU-DHL-6 211 bp overlap

ChIP SU-DHL-6 GSE134136.EZH2.SU-DHL-6 215 bp overlap

ChIP astrocyte ENCSR000ARR.EZH2.astrocyte 627 bp overlap

ChIP fibroblast_DERMAL ENCSR000ASE.EZH2.fibroblast_DERMAL 627 bp overlap

ChIP fibroblast_LUNG ENCSR000ARO.EZH2.fibroblast_LUNG 292 bp overlap

ChIP fibroblast_LUNG ENCSR000ARO.EZH2.fibroblast_LUNG 205 bp overlap

ChIP keratinocyte ENCSR000ARK.EZH2.keratinocyte 234 bp overlap

ChIP neural progenitor cell ENCFF018MKA 215 bp overlap

ChIP neural progenitor cell ENCFF472NFV 627 bp overlap

ChIP neural_progenitor ENCSR069DPL.EZH2.neural_progenitor 418 bp overlap

EZH2_phosphoT487 4 datasets

ChIP DOHH2 ENCSR562NOP.EZH2_phosphoT487.DOHH2 291 bp overlap

ChIP OCI-Ly7 ENCSR565XSL.EZH2_phosphoT487.OCI-Ly7 310 bp overlap

ChIP hepatocyte ENCSR341VYI.EZH2_phosphoT487.hepatocyte 242 bp overlap

ChIP neural_progenitor ENCSR656MXA.EZH2_phosphoT487.neural_progenitor 371 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 394 bp overlap

ChIP DE DE-GATA4-2 543 bp overlap

ChIP foregut GSE117136.GATA4.foregut 329 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 419 bp overlap

ChIP DE DE-GATA6-2 564 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 625 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 561 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 589 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 610 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 553 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 627 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 494 bp overlap

ChIP foregut GSE117136.GATA6.foregut 423 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 355 bp overlap

GLIS3 1 dataset

ChIP H9_plus GSE109562.GLIS3.H9_plus 623 bp overlap

HDAC2 4 datasets

ChIP H1 ENCFF939VKA 237 bp overlap

ChIP Hep-G2 ENCSR000BMC.HDAC2.Hep-G2 142 bp overlap

ChIP WA01 ENCSR000BNR.HDAC2.WA01 236 bp overlap

ChIP WA01 ENCSR000AVB.HDAC2.WA01 264 bp overlap

HNF4A 4 datasets

ChIP Caco-2_DIFF GSE23436.HNF4A.Caco-2_DIFF 239 bp overlap

ChIP Caco-2_PROLIF GSE23436.HNF4A.Caco-2_PROLIF 219 bp overlap

ChIP Hep-G2 ENCSR469FBY.HNF4A.Hep-G2 127 bp overlap

ChIP hiPSC GSE104613.HNF4A.hiPSC 356 bp overlap

IKZF1 2 datasets

ChIP GM12878 ENCFF824TGK 477 bp overlap

ChIP pre-B-cell GSE107886.IKZF1.pre-B-cell 226 bp overlap

JARID2 3 datasets

ChIP MRC-5_IPS25_CTR GSE48515.JARID2.MRC-5_IPS25_CTR 450 bp overlap

ChIP MRC-5_IPS25_MEG3 GSE48515.JARID2.MRC-5_IPS25_MEG3 239 bp overlap

ChIP MRC-5_IPS25_MEG3 GSE48515.JARID2.MRC-5_IPS25_MEG3 231 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 345 bp overlap

ChIP DE_D2 S54-DE-d2-JUN-exp2 295 bp overlap

ChIP ESC S24-ESC-d0-JUN-exp1 293 bp overlap

ChIP ESC S34-ESC-d0-JUN-exp2 522 bp overlap

ChIP HUES-8 GSE109524.JUN.HUES-8 503 bp overlap

JUND 2 datasets

ChIP WA01 ENCSR000BKP.JUND.WA01 113 bp overlap

ChIP WA01 ENCSR000BKP.JUND.WA01 117 bp overlap

KDM4A 2 datasets

ChIP H1 ENCFF078LED 376 bp overlap

ChIP WA01 ENCSR000AVC.KDM4A.WA01 189 bp overlap

ChIP CD4_Th1 GSE72266.MAF.CD4_Th1 166 bp overlap

ChIP NCI-H2171 GSE41105.MAX.NCI-H2171 515 bp overlap

ChIP NCI-H2171 GSE36354.MAX.NCI-H2171 342 bp overlap

ChIP WTC11 ENCFF223QFY 406 bp overlap

ChIP HEK293 GSE76494.MAZ.HEK293 152 bp overlap

MEF2B 1 dataset

ChIP GM12878 ENCSR177VFS.MEF2B.GM12878 318 bp overlap

ChIP NCI-H2171 GSE36354.MYC.NCI-H2171 340 bp overlap

NANOG 4 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 620 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 170 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 51 bp overlap

ChIP hESC GSE18292.NANOG.hESC 93 bp overlap

ChIP GM12878 ENCSR278SQL.NBN.GM12878 264 bp overlap

NEUROD1 1 dataset

ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 199 bp overlap

NFE2L1 1 dataset

ChIP WTC11 ENCFF644BPU 377 bp overlap

NFKB1 1 dataset

ChIP HEK293T GSE129618.NFKB1.HEK293T 135 bp overlap

NR2F2 3 datasets

ChIP liver ENCFF427MRU 421 bp overlap

ChIP liver ENCSR168SMX.NR2F2.liver 260 bp overlap

ChIP liver ENCSR338MMB.NR2F2.liver 235 bp overlap

PCGF1 1 dataset

ChIP WA01 GSE104690.PCGF1.WA01 552 bp overlap

POLR2A 1 dataset

ChIP spleen ENCFF044PYR 159 bp overlap

POU4F2 1 dataset

ChIP HNPC_DIF GSE74814.POU4F2.HNPC_DIF 174 bp overlap

POU5F1 2 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 288 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 627 bp overlap

RAD21 1 dataset

ChIP HEK293_siE1A GSE130135.RAD21.HEK293_siE1A 410 bp overlap

RBBP5 2 datasets

ChIP H1 ENCFF905HFL 199 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 505 bp overlap

ChIP SGBS_TNF GSE64233.RELA.SGBS_TNF 338 bp overlap

ChIP neural ENCSR000BTV.REST.neural 270 bp overlap

ChIP WA01 GSE104690.RYBP.WA01 627 bp overlap

SAP30 1 dataset

ChIP WA01 ENCSR000ATR.SAP30.WA01 307 bp overlap

SIN3A 4 datasets

ChIP H1 ENCFF042ZSL 513 bp overlap

ChIP H1 ENCFF896IJG 301 bp overlap

ChIP WA01 ENCSR000EBO.SIN3A.WA01 418 bp overlap

ChIP WA01 ENCSR000BIS.SIN3A.WA01 215 bp overlap

SMAD2-3 4 datasets

ChIP HUES-8 GSE109524.SMAD2-3.HUES-8 592 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 627 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 627 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 627 bp overlap

SMAD2_3 6 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 560 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 586 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 591 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 425 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 569 bp overlap

ChIP ESC S33-ESC-d0-SMAD2_3-exp2 556 bp overlap

SMAD3 3 datasets

ChIP BG03_DIFF_0H GSE36578.SMAD3.BG03_DIFF_0H 213 bp overlap

ChIP BG03_DIFF_2H GSE36578.SMAD3.BG03_DIFF_2H 145 bp overlap

ChIP WTC11 ENCFF815YYQ 196 bp overlap

SMARCA4 3 datasets

ChIP NSC GSE125033.SMARCA4.NSC 586 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 551 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 444 bp overlap

SMARCB1 2 datasets

ChIP hiPSC GSE124903.SMARCB1.hiPSC 401 bp overlap

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 511 bp overlap

SMARCC1 4 datasets

ChIP ESC S25-ESC-d0-BAF155-exp1 514 bp overlap

ChIP HS-SY-2 GSE108025.SMARCC1.HS-SY-2 138 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 179 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 361 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 386 bp overlap

SOX2 2 datasets

ChIP HNSC GSE69479.SOX2.HNSC 627 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 336 bp overlap

SOX21 1 dataset

ChIP neuroepithelilal-cells GSE110505.SOX21.neuroepithelilal-cells 537 bp overlap

ChIP H1 ENCFF263FUH 321 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 486 bp overlap

ChIP WTC11 ENCFF688PEU 501 bp overlap

ChIP WA01 ENCSR000BQV.SP4.WA01 277 bp overlap

ChIP WA01 ENCSR000BQV.SP4.WA01 144 bp overlap

SUZ12 5 datasets

ChIP GM12878 ENCSR091BOQ.SUZ12.GM12878 364 bp overlap

ChIP H1 ENCFF881NFR 627 bp overlap

ChIP H1 ENCFF881NFR 568 bp overlap

ChIP H1 ENCFF881NFR 189 bp overlap

ChIP WA01 ENCSR000ATS.SUZ12.WA01 271 bp overlap

TAF1 3 datasets

ChIP H1 ENCFF478SZO 467 bp overlap

ChIP H1 ENCFF478SZO 288 bp overlap

ChIP WA01 ENCSR000BHO.TAF1.WA01 131 bp overlap

TAL1 4 datasets

ChIP K-562_dCas9-LSD1 GSE132212.TAL1.K-562_dCas9-LSD1 206 bp overlap

ChIP K-562_enCRISPRi-KL GSE132212.TAL1.K-562_enCRISPRi-KL 188 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.TAL1.K-562_enCRISPRi-LK 248 bp overlap

ChIP ProEs GSE59087.TAL1.ProEs 123 bp overlap

ChIP WA01 ENCSR000ECB.TBP.WA01 181 bp overlap

TCF12 1 dataset

ChIP WA01 ENCSR000BIT.TCF12.WA01 322 bp overlap

TCF21 1 dataset

ChIP HCASMC GSE124011.TCF21.HCASMC 409 bp overlap

TCF3 2 datasets

ChIP Kasumi-1 GSE43834.TCF3.Kasumi-1 249 bp overlap

ChIP NPC GSE154479.TCF3.NPC 466 bp overlap

TEAD1 1 dataset

ChIP WTC11 ENCFF502QUV 405 bp overlap

TEAD4 1 dataset

ChIP ESC S26-ESC-d0-TEAD4-exp1 366 bp overlap

ChIP H1 ENCFF524BTL 337 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 464 bp overlap

ZBTB43 1 dataset

ChIP WTC11 ENCFF058JUB 485 bp overlap

ChIP HEK293T_FLAG GSE145160.ZFX.HEK293T_FLAG 315 bp overlap

ChIP HEK293 ENCFF033NQQ 237 bp overlap

ZNF281 2 datasets

ChIP HEK293 GSE76494.ZNF281.HEK293 151 bp overlap

ChIP WTC11 ENCFF551GAV 377 bp overlap

ZNF341 3 datasets

ChIP HEK293 ENCFF944VMC 521 bp overlap

ChIP HEK293 ENCSR185FOY.ZNF341.HEK293 598 bp overlap

ChIP HEK293 GSE76494.ZNF341.HEK293 208 bp overlap

ZNF35 1 dataset

ChIP HEK293 GSE76494.ZNF35.HEK293 172 bp overlap

ZNF398 2 datasets

ChIP HEK293 ENCFF184XEW 427 bp overlap

ChIP HEK293 ENCSR676ZEF.ZNF398.HEK293 246 bp overlap

ZNF462 2 datasets

ChIP GM23338 ENCFF896CCA 251 bp overlap

ChIP GM23338 ENCSR334UWP.ZNF462.GM23338 162 bp overlap