Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in extracellular matrix organization and nervous system development. Predicted to be located in basement membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PAPLN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAPLN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAPLN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:73,026,575–73,027,593 | 210.3 kb | Distal (>10kb) Multiome | 727 | |
| chr14:73,058,025–73,059,316 | 179.0 kb | Distal (>10kb) Multiome | 949 | |
| chr14:73,125,023–73,126,032 | 112.1 kb | Distal (>10kb) Multiome | 131 | |
| chr14:73,136,098–73,137,113 | 101.0 kb | Distal (>10kb) Multiome | 737 | |
| chr14:73,168,802–73,169,764 | 68.2 kb | Distal (>10kb) Multiome | 44 | |
| chr14:73,231,933–73,232,184 | 5.3 kb | Proximal (<10kb) | 156 | |
| chr14:73,235,444–73,236,071 | 1.7 kb | Proximal (<10kb) Multiome | 85 | |
| chr14:73,237,315–73,238,355 | 376 bp | At TSS Multiome | 296 | |
| chr14:73,239,706–73,240,073 | 2.2 kb | Proximal (<10kb) | 127 | |
| chr14:73,457,486–73,459,145 | 221.2 kb | Distal (>10kb) Multiome | 720 | |
| chr14:73,490,604–73,491,982 | 253.5 kb | Distal (>10kb) Multiome HiCAR | 866 |
Genomic view of the PAPLN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.