NFE2L1
NFE2 like bZIP transcription factor 1 | FLJ00380, LCR-F1, NRF-1, NRF1, TCF11

This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]

Biological processes 47 terms
DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)anatomical structure morphogenesis (GO:0009653)cell redox homeostasis (GO:0045454)cellular response to cholesterol (GO:0071397)cellular response to oxidative stress (GO:0034599)cholesterol binding (GO:0015485)cholesterol binding (GO:0015485)cholesterol homeostasis (GO:0042632)chromatin (GO:0000785)chromatin binding (GO:0003682)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)heme biosynthetic process (GO:0006783)identical protein binding (GO:0042802)integrated stress response signaling (GO:0140467)lipid homeostasis (GO:0055088)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)promoter-specific chromatin binding (GO:1990841)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein heterodimerization activity (GO:0046982)protein-containing complex (GO:0032991)protein-containing complex binding (GO:0044877)regulation of DNA-templated transcription (GO:0006355)regulation of odontoblast differentiation (GO:1901329)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)
Expression (TPM)
NFE2L1 — as a Regulated Gene

TFs regulating NFE2L1 0 TFs

Transcription factors with Perturb-seq knockdown data for NFE2L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFE2L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to NFE2L1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFE2L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:47,789,633–47,790,336 258.3 kb Distal (>10kb) Multiome 395
chr17:47,831,256–47,831,955 216.8 kb Distal (>10kb) Multiome 856
chr17:47,840,790–47,841,702 207.1 kb Distal (>10kb) Multiome 833
chr17:47,847,253–47,848,429 200.6 kb Distal (>10kb) Multiome 193
chr17:47,850,617–47,851,614 197.2 kb Distal (>10kb) Multiome 694
chr17:47,895,361–47,896,955 152.2 kb Distal (>10kb) Multiome 1031
chr17:47,902,020–47,902,508 146.2 kb Distal (>10kb) Multiome 101
chr17:47,941,283–47,941,880 106.8 kb Distal (>10kb) Multiome 958
chr17:47,970,487–47,971,547 77.4 kb Distal (>10kb) Multiome 1061
chr17:48,023,351–48,024,470 24.8 kb Distal (>10kb) Multiome 591
chr17:48,024,599–48,025,777 23.1 kb Distal (>10kb) Multiome 759
chr17:48,026,284–48,026,933 21.7 kb Distal (>10kb) Multiome 543
chr17:48,047,576–48,049,198 78 bp At TSS Multiome 1134
chr17:48,053,836–48,055,155 6.1 kb Proximal (<10kb) Multiome 327
chr17:48,055,581–48,056,000 7.6 kb Proximal (<10kb) Multiome 337
chr17:48,100,593–48,101,963 53.1 kb Distal (>10kb) Multiome 974
chr17:48,107,198–48,108,007 59.3 kb Distal (>10kb) Multiome 841
chr17:48,160,363–48,161,134 112.4 kb Distal (>10kb) Multiome 299

Genome Browser

Genomic view of the NFE2L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:47,779,633 – 48,171,134
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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