MEF2B

BORCS8-MEF2B readthrough | RSRFR2

This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. [provided by RefSeq, Oct 2010]

Biological processes 26 terms

DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)animal organ development (GO:0048513)cell differentiation (GO:0030154)chromatin (GO:0000785)heart development (GO:0007507)histone deacetylase binding (GO:0042826)histone deacetylase binding (GO:0042826)muscle organ development (GO:0007517)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein dimerization activity (GO:0046983)sequence-specific double-stranded DNA binding (GO:1990837)transcription regulator complex (GO:0005667)

Expression (TPM)

TFs regulating MEF2B 0 TFs

Transcription factors with Perturb-seq knockdown data for MEF2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEF2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MEF2B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEF2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:18,895,036–18,896,591	296.0 kb	Distal (>10kb) Multiome	554
chr19:18,918,971–18,919,972	272.6 kb	Distal (>10kb) Multiome	828
chr19:18,932,038–18,933,012	259.6 kb	Distal (>10kb) Multiome	312
chr19:18,940,835–18,941,417	250.9 kb	Distal (>10kb) Multiome	336
chr19:19,017,061–19,017,561	174.8 kb	Distal (>10kb) Multiome	21
chr19:19,032,820–19,034,059	158.4 kb	Distal (>10kb) Multiome	944
chr19:19,063,253–19,064,386	128.4 kb	Distal (>10kb) Multiome	781
chr19:19,105,310–19,106,514	86.4 kb	Distal (>10kb) Multiome	447
chr19:19,110,429–19,110,857	81.4 kb	Distal (>10kb) Multiome	131
chr19:19,119,998–19,121,362	71.6 kb	Distal (>10kb) Multiome	304
chr19:19,138,171–19,138,698	53.7 kb	Distal (>10kb) Multiome	642
chr19:19,170,055–19,170,692	21.8 kb	Distal (>10kb) Multiome	403
chr19:19,185,830–19,186,229	5.9 kb	Proximal (<10kb)	287
chr19:19,191,912–19,193,209	427 bp	At TSS Multiome	939
chr19:19,202,895–19,203,773	11.3 kb	Distal (>10kb) Multiome	599
chr19:19,224,938–19,225,553	33.1 kb	Distal (>10kb) Multiome	646
chr19:19,261,403–19,261,973	69.6 kb	Distal (>10kb) Multiome	205
chr19:19,272,869–19,273,464	81.0 kb	Distal (>10kb) Multiome	236
chr19:19,320,030–19,321,531	128.5 kb	Distal (>10kb) Multiome	839
chr19:19,384,944–19,386,424	193.5 kb	Distal (>10kb) Multiome	788
chr19:19,405,072–19,406,890	213.5 kb	Distal (>10kb) Multiome	1014
chr19:19,461,886–19,462,726	270.2 kb	Distal (>10kb) Multiome	345

Genome Browser

Genomic view of the MEF2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.